Eckel H E, Thumfart W F
Department of Otorhinolaryngology, University of Cologne, Germany.
Ann Otol Rhinol Laryngol. 1992 Feb;101(2 Pt 1):113-8. doi: 10.1177/000348949210100202.
The authors have developed four different types of endolaryngeal laser resections for the treatment of larynx carcinomas. These new techniques are based on traditional concepts employed in partial larynx resections. From 1986 onward, 110 patients with laryngeal cancers were treated by endoscopic laser surgery. One hundred six patients were operated on for cure and 4 for palliation. In 9 cases of T3 tumor, complete removal of the tumor was not possible, requiring total laryngectomy. In all T2 cancers of the glottis and subglottis (n = 36), a total resection was possible. Additional staged neck dissection was performed in 16 cases, and postoperative radiotherapy in 10 cases. Follow-up investigations of the patients treated for cure (n = 106) cover a period of 3 to 42 months (mean, 22 months). These revealed 6 recurrences in the larynx, which were treated by laryngectomy. Recurrences in the cervical nodes were seen in 2 patients following resection of a supraglottic tumor and a subglottic tumor, respectively. Seven patients could not be followed up, 4 patients died of intercurrent disease, and 87 patients are alive and free of tumor. At present the number of recurrences and the rate of survival show no significant difference from those previously reported after conventional surgery. The phonatory function is not always predictable and still remains to be investigated. The authors believe that laser surgery may obviate the need for total laryngectomies in selected cases of laryngeal cancer, especially in T2 tumors. However, T3 tumors should not be treated by endolaryngeal laser surgery.
作者研发了四种不同类型的喉内激光切除术用于治疗喉癌。这些新技术基于部分喉切除术所采用的传统理念。从1986年起,110例喉癌患者接受了内镜激光手术治疗。其中106例患者接受手术以根治疾病,4例为姑息治疗。在9例T3期肿瘤患者中,无法完全切除肿瘤,需要行全喉切除术。在所有声门和声门下的T2期癌症患者(n = 36)中,均可行根治性切除。16例患者额外进行了分期颈部清扫术,10例患者术后接受了放疗。对接受根治性治疗的患者(n = 106)进行了3至42个月(平均22个月)的随访调查。结果显示,有6例患者出现喉复发,均接受了喉切除术。分别有2例患者在切除声门上肿瘤和声门下肿瘤后出现颈部淋巴结复发。7例患者失访,4例患者死于并发疾病,87例患者存活且无肿瘤。目前,复发率和生存率与之前传统手术报告的结果相比无显著差异。发声功能并不总是可预测的,仍有待进一步研究。作者认为,激光手术在某些喉癌病例中,尤其是T2期肿瘤,可能无需行全喉切除术。然而,T3期肿瘤不应采用喉内激光手术治疗。