Ocarino N M, Marubayashi U, Cardoso T G, Guimaraes C V, Silva A E, Torres R C, Serakides R
Departamento de Clinica e Cirurgia Veterinarias, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
J Musculoskelet Neuronal Interact. 2007 Jan-Mar;7(1):84-93.
The effect of physical activity in the treatment of osteopenia induced by ovariectomy was studied in 34 two-month-old Wistar female rats. Animals were divided into three groups in which two were formed by ovariectomized (OVX) animals and the other one had sham-operated animals. Group 1, active OVX'd rats; group 2, sedentary OVX'd rats and group 3, sham-operated ones (control). After three months of daily physical activity in a motor-driven treadmill all rats were sacrificed. In order to perform a histomorphometric analysis, long bones, vertebrae, and nasal bone were selected at necropsy. Ovariectomized rats which exercised showed an increased trabecular bone volume, cortical thickness in the long bones and vertebrae and also an increased nasal bone thickness. Physical activity also increased the connection of osteocytes. It was concluded that physical activity in osteopenia treatment increases and restores the mass of bones directly and indirectly submitted to physical impact.
在34只两个月大的雌性Wistar大鼠中研究了体育活动对卵巢切除诱导的骨质减少的治疗效果。动物被分为三组，其中两组由卵巢切除（OVX）的动物组成，另一组是假手术动物。第1组，活跃的卵巢切除大鼠；第2组，久坐的卵巢切除大鼠；第3组，假手术大鼠（对照组）。在电动跑步机上进行三个月的每日体育活动后，所有大鼠均被处死。为了进行组织形态计量分析，在尸检时选择了长骨、椎骨和鼻骨。进行运动的卵巢切除大鼠显示骨小梁体积增加、长骨和椎骨的皮质厚度增加，鼻骨厚度也增加。体育活动还增加了骨细胞的连接。得出的结论是，体育活动在骨质减少治疗中直接和间接地增加并恢复了受到身体冲击的骨骼质量。
