Winocur Gordon, Moscovitch Morris, Sekeres Melanie
Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada.
Nat Neurosci. 2007 May;10(5):555-7. doi: 10.1038/nn1880. Epub 2007 Apr 1.
The traditional view is that the hippocampus is necessary for retaining memories until they are consolidated in their original form in the neocortex. An alternative view is that the original memory, which is hippocampus- and context-dependent, becomes transformed with time to one that is more schematic and independent of the hippocampus. By manipulating context in two protocols that are widely used to investigate hippocampal-neocortical interactions in memory, we find evidence for the transformation view.
传统观点认为，海马体对于记忆的保留是必要的，直到这些记忆在新皮层中以其原始形式得到巩固。另一种观点则认为，最初依赖海马体和情境的记忆会随着时间的推移转变为一种更具模式化且独立于海马体的记忆。通过在两种广泛用于研究记忆中海马体 - 新皮层相互作用的实验方案中操纵情境，我们找到了支持这种转变观点的证据。
