富克斯异色性葡萄膜炎是否存在遗传基础？同卵双胞胎的不一致情况。

Department of Ophthalmology, University of Manchester.

Br J Ophthalmol. 1992 Jan;76(1):22-4. doi: 10.1136/bjo.76.1.22.

One pair, and probably two pairs, of monozygotic twins are reported with discordance for Fuchs' heterochromic uveitis (FHU). Regular Mendelian inheritance of this disease is now proved to be impossible. The heritability of FHU is low and may be zero. The possibility of any genetic predisposition to the disease and its association with 'simple' heterochromia are discussed.

据报道，有一对，可能还有两对同卵双胞胎患富克斯异色性葡萄膜炎（FHU）的情况不一致。现已证明，这种疾病不可能遵循孟德尔遗传规律。FHU的遗传度很低，可能为零。本文讨论了该病存在任何遗传易感性的可能性及其与“单纯”异色症的关联。