Saari M, Vuorre I, Tiilikainen A, Algvere P
Can J Ophthalmol. 1978 Oct;13(4):240-6.
We studied the genetic background of 24 patients with Fuchs' heterochromic cyclitis (FHC). Each was given a careful eye examination which included family history and serological determination of HLA antigens. Two families each had 2 cases of FHC in the same family; in addition an ancestor in the second family possibly had FHC; in both families one healthy member had simple heterochromia. One patient with FHC had congenital uveal coloboma, one pigmentary retinal dystrophy, and four had cysts of the ciliary body. The frequencies of all HLA antigens in patients with FHC compared well with the frequencies in the controls. In a family in which HLA haplotypes could be derived, the patients with FHC showed different HLA haplotypes. We conclude that FHC has a hereditary basis but its immunological component is not genetically associated with the HLA system.
我们研究了24例富克斯异色性睫状体炎（FHC）患者的遗传背景。对每位患者都进行了仔细的眼部检查，包括家族史和HLA抗原的血清学测定。有两个家族各有2例家族性FHC；此外，第二个家族的一位祖先可能患有FHC；在这两个家族中，各有一名健康成员有单纯性异色症。1例FHC患者合并先天性葡萄膜缺损，1例合并色素性视网膜营养不良，4例有睫状体囊肿。FHC患者中所有HLA抗原的频率与对照组的频率相当。在一个可以推导HLA单倍型的家族中，FHC患者表现出不同的HLA单倍型。我们得出结论，FHC有遗传基础，但其免疫成分与HLA系统无遗传关联。
