Muñoz G, López-Corell M P, Taboada J F, Ferrer E, Díaz-Llopis M
La Fe University Hospital, Department of Surgery, University of Valencia, Spain.
Int Ophthalmol. 1994;18(3):127-30. doi: 10.1007/BF00915960.
Genetic typing of class I major histocompatibility complex (MHC) antigens (HLA-A, -B and -C) was performed in 22 patients with Fuch's heterochromic cyclitis (FHC) and in a control group of 339 healthy subjects in order to ascertain whether there are any genetic factors that protect against or increase the risk of developing this disease. The frequency of only one HLA-antigen was found to differ significantly in the patients with FHC as compared with the normal subjects: HLA-A2 had a negative association with FHC (9.09% in FHC verus 47.47% in the control group; p < 0.01, Fisher's exact test with correction for the number of antigens studied) with an odds ratio of 0.11 (95% confidence limits 0.03 and 0.50). Other HLA antigens also showed a negative or positive association with FHC but not to a statistically significant level. Our results suggest a possible role for HLA genetic factors in the pathogenesis of FHC.
对22例富克斯异色性睫状体炎（FHC）患者和339名健康对照者进行了I类主要组织相容性复合体（MHC）抗原（HLA - A、- B和 - C）的基因分型，以确定是否存在任何可预防或增加患此病风险的遗传因素。与正常受试者相比，仅发现一种HLA抗原在FHC患者中的频率有显著差异：HLA - A2与FHC呈负相关（FHC患者中为9.09%，对照组中为47.47%；p < 0.01，经研究抗原数量校正的Fisher精确检验），优势比为0.11（95%置信区间为0.03和0.50）。其他HLA抗原与FHC也显示出负相关或正相关，但未达到统计学显著水平。我们的结果提示HLA遗传因素在FHC发病机制中可能起作用。
