Kelly Kimberly M, Andrews James E, Case Donald O, Allard Suzanne L, Johnson J David
Human Cancer Genetics, the Ohio State University, Columbus, Ohio 43210, USA.
J Rural Health. 2007 Spring;23(2):166-72. doi: 10.1111/j.1748-0361.2007.00085.x.
Research is limited regarding the potential of genetic testing for cancer risk in rural Appalachia.
This study examined perceptions of genetic testing in a population sample of Kentuckians, with a focus on Appalachian and rural differences. The goals were to examine cultural and psychosocial factors that may predict intentions to test for hereditary cancer, need for help with information seeking for decision making about genetic testing for hereditary cancer, and amount of help needed with information seeking for decision making about genetic testing for hereditary cancer in this population.
Analysis of data from a general social survey of adults using random-digit dialing in Kentucky (N = 882).
An ordinal regression found that younger age, having a family history of cancer, and greater worry predicted greater intentions to seek genetic testing. A logistic regression found that having more education, excellent subjective knowledge of genetics, and less worry about cancer predicted less need for help in seeking information about testing. An ordinal regression found that less subjective knowledge of genetics and greater worry predicted greater amount of help needed.
Additional counseling to explain limitations of genetic testing may be needed. Further, those with less knowledge about genetics and more worry about hereditary cancer may have greater need for help with information seeking for decision making, a need that may be further exacerbated by the lack of medical professionals, particularly genetic counselors, who may provide information about genetic testing in rural, Appalachian Kentucky.
关于阿巴拉契亚农村地区癌症风险基因检测潜力的研究有限。
本研究调查了肯塔基州人群样本对基因检测的看法，重点关注阿巴拉契亚地区与农村地区的差异。目标是研究可能预测遗传性癌症检测意愿的文化和心理社会因素、在遗传性癌症基因检测决策的信息寻求方面对帮助的需求，以及该人群在遗传性癌症基因检测决策的信息寻求方面所需帮助的程度。
对肯塔基州使用随机数字拨号进行的成年人综合社会调查数据（N = 882）进行分析。
有序回归分析发现，年龄较小、有癌症家族史以及担忧程度较高预示着寻求基因检测的意愿更强。逻辑回归分析发现，受教育程度更高、对遗传学有出色的主观知识以及对癌症的担忧较少预示着在检测信息寻求方面对帮助的需求较少。有序回归分析发现，对遗传学的主观知识较少以及担忧程度较高预示着所需帮助的程度更大。
可能需要额外的咨询来解释基因检测的局限性。此外，那些对遗传学知识了解较少且对遗传性癌症担忧较多的人在遗传性癌症检测决策的信息寻求方面可能更需要帮助，而肯塔基州农村阿巴拉契亚地区缺乏可能提供基因检测信息的医疗专业人员，尤其是遗传咨询师，这一需求可能会进一步加剧。
