Greenstein A J, Mullin G E, Strauchen J A, Heimann T, Janowitz H D, Aufses A H, Sachar D B
Department of Surgery, Mount Sinai School of Medicine, City University of New York, New York.
Cancer. 1992 Mar 1;69(5):1119-23. doi: 10.1002/cncr.2820690510.
Nine patients with lymphoma occurring in association with inflammatory bowel disease were admitted to The Mount Sinai Hospital between 1960 and 1983. Five (two men and three women) occurred among 1156 patients (0.43%) with ulcerative colitis (UC) and four (men), among 1480 patients (0.27%) with Crohn's disease (CD), a strong male preponderance in the latter group. In all four of the patients with CD and in four of the five patients with UC, the lymphomas were extraintestinal. The mean age of onset of UC in these patients was late (46 years, 19 years older than in our overall series), with lymphomas occurring a mean of only 12 years later. By contrast, patients with CD had bowel disease much younger (mean age, 26 years), and their lymphomas appeared after a longer disease duration (mean, 24 years). The risk factors for the one patient with colonic lymphoma were similar to those with colitis-associated colorectal carcinoma: extensive and long-standing colitis and relatively young age when malignant disease developed. Four of the patients with lymphoma had associated colonic carcinoma; in three of them, the carcinoma appeared within the first decade of colitis, an unusual occurrence. A second malignant lesion also occurred in three patients with UC.
1960年至1983年间，有9例淋巴瘤患者因炎症性肠病入住西奈山医院。其中5例（2名男性和3名女性）出现在1156例溃疡性结肠炎（UC）患者中（0.43%），4例（男性）出现在1480例克罗恩病（CD）患者中（0.27%），后一组男性占比极高。在所有4例CD患者和5例UC患者中的4例中，淋巴瘤为肠外病变。这些UC患者的平均发病年龄较晚（46岁，比我们的总体系列患者大19岁），淋巴瘤平均仅在12年后出现。相比之下，CD患者的肠道疾病发病年龄要小得多（平均年龄26岁），他们的淋巴瘤在疾病持续较长时间（平均24年）后出现。1例结肠淋巴瘤患者的危险因素与结肠炎相关的结直肠癌患者相似：广泛且长期的结肠炎以及恶性疾病发生时相对年轻的年龄。4例淋巴瘤患者伴有结肠癌；其中3例，癌症在结肠炎的第一个十年内出现，这是不寻常的情况。3例UC患者还出现了第二种恶性病变。
