Greenstein A J, Sachar D B, Smith H, Janowitz H D, Aufses A H
Cancer. 1980 Jul 15;46(2):403-7. doi: 10.1002/1097-0142(19800715)46:2<403::aid-cncr2820460232>3.0.co;2-6.
Cancer occurred in 28 of 579 patients (4.8%) with Crohn's disease (CD) and in 30 of 267 (11.2%) with ulcerative colitis (UC) admitted to the Mount Sinai Hospital between 1960--1976. The proportion of cancers that were extraintestinal was greater in CD than in UC (43 vs. 12%), as was the proportion of gastrointestinal cancers that arose in apparently normal bowels (33 vs. 4%). The incidence of gastrointestinal cancer increase with duration of disease in both CD and UC, but the absolute rates were three times higher in UC. For extraintestinal cancer, on the other hand, there was less correlation with increasing duration of disease, and no higher frequency in UC than in CD. Mortality from gastrointestinal cancer was 82% in CD and 50% in UC, but occurred only within two years of tumor diagnosis; survival beyond two years seemed to indicate a favorable prognosis.
1960年至1976年间，在西奈山医院收治的579例克罗恩病（CD）患者中，有28例（4.8%）发生癌症；267例溃疡性结肠炎（UC）患者中，有30例（11.2%）发生癌症。CD患者中肠外癌症的比例高于UC患者（43%对12%），在明显正常肠段发生的胃肠道癌症比例也是如此（33%对4%）。CD和UC患者中胃肠道癌症的发病率均随病程延长而增加，但UC患者的绝对发病率是CD患者的三倍。另一方面，对于肠外癌症，其与病程延长的相关性较小，UC患者的发病率并不高于CD患者。CD患者胃肠道癌症的死亡率为82%，UC患者为50%，但均仅发生在肿瘤诊断后的两年内；超过两年的生存期似乎预示着预后良好。
