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方形微通道内血流的体外共聚焦显微粒子图像测速测量:血细胞比容对瞬时速度剖面的影响

In vitro confocal micro-PIV measurements of blood flow in a square microchannel: the effect of the haematocrit on instantaneous velocity profiles.

作者信息

Lima Rui, Wada Shigeo, Takeda Motohiro, Tsubota Ken-ichi, Yamaguchi Takami

机构信息

Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aoba, 980-8579 Sendai, Japan.

出版信息

J Biomech. 2007;40(12):2752-7. doi: 10.1016/j.jbiomech.2007.01.012. Epub 2007 Mar 30.

DOI:10.1016/j.jbiomech.2007.01.012
PMID:17399723
Abstract

A confocal microparticle image velocimetry (micro-PIV) system was used to obtain detailed information on the velocity profiles for the flow of pure water (PW) and in vitro blood (haematocrit up to 17%) in a 100-microm-square microchannel. All the measurements were made in the middle plane of the microchannel at a constant flow rate and low Reynolds number (Re=0.025). The averaged ensemble velocity profiles were found to be markedly parabolic for all the working fluids studied. When comparing the instantaneous velocity profiles of the three fluids, our results indicated that the profile shape depended on the haematocrit. Our confocal micro-PIV measurements demonstrate that the root mean square (RMS) values increase with the haematocrit implying that it is important to consider the information provided by the instantaneous velocity fields, even at low Re. The present study also examines the potential effect of the RBCs on the accuracy of the instantaneous velocity measurements.

摘要

采用共聚焦微粒图像测速系统(显微粒子图像测速技术)获取了纯水(PW)和体外血液(血细胞比容高达17%)在100微米见方微通道中流动的速度剖面详细信息。所有测量均在微通道的中间平面以恒定流速和低雷诺数(Re = 0.025)进行。对于所有研究的工作流体,发现平均总体速度剖面明显呈抛物线形。比较三种流体的瞬时速度剖面时,我们的结果表明剖面形状取决于血细胞比容。我们的共聚焦显微粒子图像测速测量表明,均方根(RMS)值随血细胞比容增加,这意味着即使在低雷诺数下,考虑瞬时速度场提供的信息也很重要。本研究还考察了红细胞对瞬时速度测量准确性的潜在影响。

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