薯蓣科植物多裂叶薯蓣块茎中的多羟基螺旋甾烷醇皂苷。

Polyhydroxylated spirostanol saponins from the tubers of Dioscorea polygonoides.

作者信息

Osorio Jaime Niño, Mosquera Martinez Oscar M, Correa Navarro Yaned M, Watanabe Kazuki, Sakagami Hiroshi, Mimaki Yoshihiro

机构信息

Grupo de Biotecnología-Productos Naturales, Escuela de Tecnología Química, Universidad Tecnológica de Pereira, La Julita, A. A. 97 Pereira, Colombia.

出版信息

J Nat Prod. 2005 Jul;68(7):1116-20. doi: 10.1021/np0580356.

DOI:10.1021/np0580356

PMID:16038563

Abstract

Three new polyhydroxylated spirostanol saponins (1-3) were isolated from the tubers of Dioscorea polygonoides. The structures of these new compounds were determined on the basis of extensive spectroscopic analysis and the results of acid or enzymatic hydrolysis as (23S,24R,25S)-23,24-dihydroxyspirost-5-en-3beta-yl O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside (1), (23S,25R)-12alpha,17alpha,23-trihydroxyspirost-5-en-3beta-yl O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside (2), and (23S,25R)-14alpha,17alpha,23-trihydroxyspirost-5-en-3beta-yl O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside (3), respectively.

摘要

从多花薯蓣的块茎中分离出三种新的多羟基螺旋甾烷醇皂苷（1-3）。基于广泛的光谱分析以及酸或酶水解结果，确定这些新化合物的结构分别为（23S，24R，25S）-23,24-二羟基螺旋甾-5-烯-3β-基O-α-L-鼠李吡喃糖基-（1→2）-β-D-吡喃葡萄糖苷（1）、（23S，25R）-12α，17α，23-三羟基螺旋甾-5-烯-3β-基O-α-L-鼠李吡喃糖基-（1→2）-β-D-吡喃葡萄糖苷（2）和（23S，25R）-14α，17α，23-三羟基螺旋甾-5-烯-3β-基O-α-L-鼠李吡喃糖基-（1→2）-β-D-吡喃葡萄糖苷（3）。