表达质粒携带喹诺酮耐药决定子qnrA1的肠杆菌科细菌对氟喹诺酮类药物的突变预防浓度
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.
作者信息
Rodríguez-Martínez J M, Velasco C, García I, Cano M E, Martínez-Martínez L, Pascual A
机构信息
Department of Microbiology, University of Seville, Sanchez Pizjuan s/n, Seville 41009, Spain.
出版信息
Antimicrob Agents Chemother. 2007 Jun;51(6):2236-9. doi: 10.1128/AAC.01444-06. Epub 2007 Apr 2.
Abstract
The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1, mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.
摘要
通过使用突变预防浓度参数评估了qnrA1对肠杆菌科细菌喹诺酮耐药性发展的影响。与没有该基因的菌株相比，qnrA1的表达显著提高了突变预防浓度。在qnrA1存在的情况下，gyrA和parC基因的突变很容易被选择出来，从而产生高水平的喹诺酮耐药性。
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