Zhang Jian-Ting
Department of Pharmacology and Toxicology, Walther Oncology Center/Walther Cancer Institute and IU Cancer Center, Indiana University School of Medicine, 1044 W. Walnut Street, R4-166, Indianapolis, IN 46202, USA.
Cell Res. 2007 Apr;17(4):311-23. doi: 10.1038/cr.2007.15.
Multidrug resistance (MDR) is a major problem in cancer chemotherapy. One of the best known mechanisms of MDR is the elevated expression of ATP-binding cassette (ABC) transporters. While some members of human ABC transporters have been shown to cause drug resistance with elevated expression, it is not yet known whether the over-expression of other members could also contribute to drug resistance in many model cancer cell lines and clinics. The recent development of microarrays and quantitative PCR arrays for expression profiling analysis of ABC transporters has helped address these issues. In this article, various arrays with limited or full list of ABC transporter genes and their use in identifying ABC transporter genes in drug resistance and chemo-sensitivity prediction will be reviewed.
多药耐药（MDR）是癌症化疗中的一个主要问题。MDR最广为人知的机制之一是ATP结合盒（ABC）转运蛋白的表达升高。虽然已表明人类ABC转运蛋白的一些成员在表达升高时会导致耐药，但在许多模型癌细胞系和临床中，其他成员的过表达是否也会导致耐药尚不清楚。用于ABC转运蛋白表达谱分析的微阵列和定量PCR阵列的最新发展有助于解决这些问题。本文将综述具有有限或完整ABC转运蛋白基因列表的各种阵列及其在识别耐药和化疗敏感性预测中的ABC转运蛋白基因方面的应用。
