Atkins P C, Kaplan A P, von Allmen C, Moskovitz A, Zweiman B
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104.
J Allergy Clin Immunol. 1992 Feb;89(2):552-9. doi: 10.1016/0091-6749(92)90322-s.
The levels of histamine, fibrinopeptide A (FPA), and IgG were determined in chamber fluids overlying sites of antigen versus buffer incubation for up to 7 hours in seven atopic and four antigen-nonreactive subjects. Significant increases in histamine were observed at antigen versus buffer sites in the atopic subjects throughout the 7-hour period. FPA and IgG levels were higher in antigen than in buffer sites from 0 to 5 hours in the atopic subjects. Furthermore, FPA levels correlated with the magnitude of induration at 6 hours after antigen injection in atopic subjects. There were no differences in the levels of histamine, FPA, or IgG at antigen versus buffer sites in the skin test-negative subjects. We suggest that the combination of vascular leakage of proteins, induced by vasoactive mediator release, and activation of these proteins during ongoing cutaneous reactions is responsible for fibrin formation that contributes to the pathophysiology of late-phase allergic responses in the skin.
在7名特应性个体和4名抗原无反应性个体中，测定了在抗原与缓冲液孵育部位上方的腔室液中组胺、纤维蛋白肽A（FPA）和IgG的水平，孵育时间长达7小时。在整个7小时期间，特应性个体的抗原部位相对于缓冲液部位观察到组胺显著增加。在特应性个体中，从0到5小时，抗原部位的FPA和IgG水平高于缓冲液部位。此外，特应性个体在注射抗原后6小时，FPA水平与硬结大小相关。皮肤试验阴性个体的抗原部位与缓冲液部位的组胺、FPA或IgG水平没有差异。我们认为，血管活性介质释放诱导的蛋白质血管渗漏与皮肤持续反应期间这些蛋白质的激活相结合，导致了纤维蛋白形成，这有助于皮肤迟发性过敏反应的病理生理过程。
