Sengupta S, Sasisekharan R
BWH-HST Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Cambridge, MA 02139, USA.
Br J Cancer. 2007 May 7;96(9):1315-9. doi: 10.1038/sj.bjc.6603707. Epub 2007 Apr 3.
Nanotechnology is increasingly finding use in the management of cancer. Nanoscale devices have impacted cancer biology at three levels: early detection using, for example, nanocantilevers or nanoparticles; tumour imaging using radiocontrast nanoparticles or quantum dots; and drug delivery using nanovectors and hybrid nanoparticles. This review addresses some of the major milestones in the integration of nanotechnology and cancer biology, and the future of nanoscale approaches for cancer management.
纳米技术在癌症治疗中的应用越来越广泛。纳米级装置已在三个层面影响癌症生物学:一是早期检测,例如使用纳米悬臂梁或纳米颗粒;二是肿瘤成像,使用放射性造影纳米颗粒或量子点;三是药物递送,使用纳米载体和混合纳米颗粒。本文综述了纳米技术与癌症生物学整合方面的一些主要里程碑,以及纳米级癌症治疗方法的未来发展。