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1
The effect of nerve growth factor on cycle AMP levels in superior cerival ganglia of the rat.神经生长因子对大鼠颈上神经节中环磷酸腺苷水平的影响。
Proc Natl Acad Sci U S A. 1975 Dec;72(12):4769-71. doi: 10.1073/pnas.72.12.4769.
2
Increased phosphorylation of specific nuclear proteins in superior cervical ganglia and PC12 cells in response to nerve growth factor.响应神经生长因子时，颈上神经节和PC12细胞中特定核蛋白的磷酸化增加。
J Biol Chem. 1980 Nov 10;255(21):10481-92.
3
Is there a second messenger for nerve growth factor-induced phosphatidylinositol turnover in rat superior cervical ganglia?
Brain Res. 1978 Nov 17;157(1):173-7. doi: 10.1016/0006-8993(78)91009-0.
4
Mutually independent cyclic AMP and sodium responses to nerve growth factor in embryonic chick dorsal root ganglia.胚胎鸡背根神经节中对神经生长因子的环磷酸腺苷和钠反应相互独立
J Neurochem. 1981 Jul;37(1):222-8. doi: 10.1111/j.1471-4159.1981.tb05312.x.
5
Effects of nerve growth factor on cyclic AMP levels in embryonic chick dorsal root ganglia following factor deprivation.神经生长因子剥夺后对胚胎鸡背根神经节中环磷酸腺苷水平的影响。
J Neurochem. 1979 Jun;32(6):1845-51. doi: 10.1111/j.1471-4159.1979.tb02299.x.
6
Nerve growth factor-mediated induction of tyrosine hydroxylase in rat superior cervical ganglia in vitro.神经生长因子介导的体外大鼠颈上神经节酪氨酸羟化酶的诱导
J Biol Chem. 1978 Nov 25;253(22):8013-5.
7
Nerve growth factor: relationship to the cyclic AMP system of sensory ganglia.神经生长因子：与感觉神经节环磷酸腺苷系统的关系
Science. 1973 Oct 5;182(4107):79-81. doi: 10.1126/science.182.4107.79.
8
Effects of nerve growth factor and nerve growth factor antiserum on tyrosine hydroxylase and dihydropterine reductase activities in rat superior cervical ganglia in vivo.神经生长因子和神经生长因子抗血清对大鼠颈上神经节中酪氨酸羟化酶和二氢蝶呤还原酶活性的体内影响。
J Neurochem. 1977 Apr;28(4):851-2. doi: 10.1111/j.1471-4159.1977.tb10637.x.
9
Nerve growth factor stimulates the development of substance P in sensory ganglia.神经生长因子刺激感觉神经节中P物质的发育。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):649-52. doi: 10.1073/pnas.77.1.649.
10
cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.环磷酸腺苷（cAMP）类似物可促进大鼠交感神经元和感觉神经元培养物的存活及神经突生长，且与神经生长因子无关。
Proc Natl Acad Sci U S A. 1988 Feb;85(4):1257-61. doi: 10.1073/pnas.85.4.1257.

引用本文的文献

1
Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases.神经生长因子的作用由环磷酸腺苷和钙/磷脂依赖性蛋白激酶介导。
J Cell Biol. 1986 Sep;103(3):887-93. doi: 10.1083/jcb.103.3.887.
2
Intraventricular administration of nerve growth factor induces ornithine decarboxylase in peripheral tissues of the rat.脑室内注射神经生长因子可诱导大鼠外周组织中的鸟氨酸脱羧酶。
Proc Natl Acad Sci U S A. 1978 May;75(5):2512-5. doi: 10.1073/pnas.75.5.2512.
3
Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglia of young rats.神经生长因子可增加幼鼠颈上神经节中鸟氨酸脱羧酶的活性。
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4681-4. doi: 10.1073/pnas.74.10.4681.
4
Growth regulation by nerve growth factor.神经生长因子对生长的调节作用。
Mol Cell Biochem. 1979 Dec 14;28(1-3):67-91. doi: 10.1007/BF00223360.
5
Control of adenylate cyclase from secretory vesicle membranes by beta-adrenergic agents and nerve growth factor.β-肾上腺素能药物和神经生长因子对分泌囊泡膜腺苷酸环化酶的调控
Proc Natl Acad Sci U S A. 1976 Mar;73(3):771-4. doi: 10.1073/pnas.73.3.771.

本文引用的文献

1
METABOLIC ASPECTS OF THE EFFECT OF NERVE GROWTH FACTOR ON SYMPATHETIC AND SENSORY GANGLIA: PROTEIN AND RIBONUCLEIC ACID SYNTHESIS.神经生长因子对交感神经节和感觉神经节作用的代谢方面：蛋白质与核糖核酸合成
Biochim Biophys Acta. 1965 Jan 11;95:111-20. doi: 10.1016/0005-2787(65)90216-9.
2
Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro.神经生长因子在体外对解离的胚胎感觉和交感神经细胞存活及维持方面的重要作用。
Dev Biol. 1963 Mar;6:653-9. doi: 10.1016/0012-1606(63)90149-0.
3
Metabolic effects of a specific nerve growth factor (NGF) on sensory and sympathetic ganglia: enhancement of lipid biosynthesis.
J Neurochem. 1965 Aug;12(8):705-8. doi: 10.1111/j.1471-4159.1965.tb06784.x.
4
Glucose metabolism in embryonic ganglia: effect of nerve growth factor [NGF] and insulin.胚胎神经节中的葡萄糖代谢：神经生长因子[NGF]和胰岛素的作用。
Brain Res. 1968 Mar;7(3):452-4. doi: 10.1016/0006-8993(68)90011-5.
5
Tissue culture assay of nerve growth factor and of the specific antiserum.神经生长因子及特异性抗血清的组织培养测定
Exp Cell Res. 1970 Mar;59(3):383-92. doi: 10.1016/0014-4827(70)90645-2.
6
The nerve growth factor: its mode of action on sensory and sympathetic nerve cells.神经生长因子：其对感觉神经细胞和交感神经细胞的作用方式。
Harvey Lect. 1966;60:217-59.
7
Selective induction by nerve growth factor of tyrosine hydroxylase and dopamine- -hydroxylase in the rat superior cervical ganglia.神经生长因子对大鼠颈上神经节中酪氨酸羟化酶和多巴胺-β-羟化酶的选择性诱导作用。
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1598-602. doi: 10.1073/pnas.68.7.1598.
8
The role of nerve growth factor in the ramification of sympathetic nerve fibres into the rat iris in organ culture.神经生长因子在器官培养中对大鼠虹膜交感神经纤维分支形成的作用。
J Neurochem. 1972 Sep;19(9):2025-9. doi: 10.1111/j.1471-4159.1972.tb05112.x.
9
Nerve growth factor and insulin.神经生长因子与胰岛素。
Science. 1972 May 5;176(4034):482-8. doi: 10.1126/science.176.4034.482.
10
The role of the tryptophan residues in the activity of the nerve growth factor.色氨酸残基在神经生长因子活性中的作用。
Biochim Biophys Acta. 1970 Sep 29;214(3):478-82. doi: 10.1016/0005-2795(70)90307-7.

神经生长因子对大鼠颈上神经节中环磷酸腺苷水平的影响。

The effect of nerve growth factor on cycle AMP levels in superior cerival ganglia of the rat.

作者信息

Nikodijevic B, Nikodijevic O, Yu M Y, Pollard H, Guroff G

出版信息

Proc Natl Acad Sci U S A. 1975 Dec;72(12):4769-71. doi: 10.1073/pnas.72.12.4769.

DOI:10.1073/pnas.72.12.4769
PMID:174074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388812/
Abstract

Nerve growth factor (NGF) produces a several-fold increase in the cyclic AMP concentration in rat superior cervical ganglia in organ culture within 5 min. An increase can be seen with as little as 40 ng/ml of NGF. Oxidized NGF is without effect. The increase in the cAMP concentration produced by NGF is prevented by the addition of antiserum to NGF.

摘要

神经生长因子（NGF）可在5分钟内使器官培养的大鼠颈上神经节中的环磷酸腺苷（cAMP）浓度增加数倍。低至40 ng/ml的NGF即可产生这种增加。氧化型NGF则无此作用。添加NGF抗血清可阻止NGF所引起的cAMP浓度升高。