Clarke Lorcan, Clarke Mike, Clarke Thomas
UK Cochrane Centre, NHS R&D Programme, Oxford, UK.
J Health Serv Res Policy. 2007 Apr;12(2):101-3. doi: 10.1258/135581907780279648.
To determine the extent to which reports of Cochrane reviews recommend the need for further research and, if so, the extent to which they make suggestions regarding that research.
We examined all 2535 reviews in Issue 4, 2005 of The Cochrane Library. Each review was categorized on the basis of whether a suggestion was included about specific interventions, participants, or outcome measures that should be included in future research. We also identified the frequency with which reviews conclude that no more research is needed or feasible, noted the need for further systematic reviewing, and refered to a relevant ongoing or planned study. We also report the number of studies listed in the 'Ongoing Studies' section in each review.
Only 3.2% of reviews suggested explicitly that no more research is needed or feasible. In 82.0% of reviews, suggestions were made as to the specific interventions that need evaluating, in 30.2% the appropriate participants were suggested, and in 51.9% outcome measures were suggested. Suggestions for all three domains were made in 16.9% of the reviews. While 11.6% did not include a specific suggestion about any of these domains, 21.2% of reviews mention a relevant ongoing or planned study in one or both of the 'Implications for Research' and the 'Ongoing Studies' sections.
Most Cochrane reviews identify residual uncertainty and are a rich source of suggestions for further health-care research.
确定Cochrane系统评价报告推荐进一步研究的必要性的程度，若有推荐，确定其对该研究提出建议的程度。
我们查阅了《Cochrane图书馆》2005年第4期的所有2535篇系统评价。每篇系统评价根据是否包含关于未来研究应纳入的具体干预措施、参与者或结局指标的建议进行分类。我们还确定了系统评价得出不再需要或不可行进行更多研究的频率，记录了进一步进行系统评价的必要性，并提及了相关的正在进行或计划中的研究。我们还报告了每篇系统评价“正在进行的研究”部分列出的研究数量。
只有3.2%的系统评价明确建议不再需要或不可行进行更多研究。在82.0%的系统评价中，针对需要评估的具体干预措施提出了建议，30.2%的系统评价建议了合适的参与者，51.9%的系统评价建议了结局指标。16.9%的系统评价针对所有三个领域都提出了建议。虽然11.6%的系统评价未针对这些领域中的任何一个提出具体建议，但21.2%的系统评价在“研究意义”和“正在进行的研究”部分中的一个或两个部分提到了相关的正在进行或计划中的研究。
大多数Cochrane系统评价识别出了残留的不确定性，是进一步卫生保健研究建议的丰富来源。
