Loyke H F, Maksem J A
St. Vincent Charity Hospital and Health Center, Cleveland, OH 44115.
J Environ Pathol Toxicol Oncol. 1992 Jan-Feb;11(1):38-42.
Renal hypertension has been reduced to normal levels in the rat with subcutaneous injections of carbon tetrachloride (CCl4). Previous light microscopic evaluation of liver sections demonstrated varying degrees of hepatocellular and hepatic parenchymal injury secondary to CCl4 administration. In normotensive rat populations, saline injections have been shown not to cause hypertension, and the treatment of normal rats with subcutaneous CCl4 did not change their blood pressure over that of noninjected controls. In this study we compare the extent of blood pressure reduction with the degree of CCl4-induced liver injury in the renal-induced, spontaneous hypertensive rat (SHR), and normotensive rat. Statistically significant blood pressure reduction followed CCl4 injection of renal (p less than .01) and SHR (p less than .001) hypertensive animals. The morphological liver injury appeared most sensitively reflected in hepatocellular nuclear atypia. The SHR animals were the most resistant to CCl4 liver damage by chronic CCl4 treatment. There was no measurable effect of CCl4 treatment on the animals as assessed by their activity, rate of development and weight gain. The degree of blood pressure reduction due to CCl4 treatment in the SHR animals was similar to that previously reported in DOCA and renal-induced hypertensive animals.
通过皮下注射四氯化碳（CCl4），大鼠的肾性高血压已降至正常水平。先前对肝脏切片的光学显微镜评估显示，给予CCl4后肝细胞和肝实质出现不同程度的损伤。在正常血压大鼠群体中，注射生理盐水未显示会导致高血压，对正常大鼠皮下注射CCl4也未使其血压相对于未注射的对照组发生变化。在本研究中，我们比较了肾性自发性高血压大鼠（SHR）和正常血压大鼠中血压降低程度与CCl4诱导的肝损伤程度。对肾性（p<0.01）和SHR（p<0.001）高血压动物注射CCl4后，血压出现了具有统计学意义的降低。肝形态学损伤最敏感地反映在肝细胞核异型性上。通过慢性CCl4处理，SHR动物对CCl4肝损伤的抵抗力最强。根据动物的活动、发育速度和体重增加情况评估，CCl4处理对动物没有可测量的影响。SHR动物中因CCl4处理导致的血压降低程度与先前在去氧皮质酮（DOCA）和肾性高血压动物中报道的相似。
