Rossi L, Foffani G, Marceglia S, Bracchi F, Barbieri S, Priori A
Dipartimento di Scienze Neurologiche, Università degli Studi di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy.
J Neural Eng. 2007 Jun;4(2):96-106. doi: 10.1088/1741-2560/4/2/010. Epub 2007 Mar 13.
The clinical efficacy of high-frequency deep brain stimulation (DBS) for Parkinson's disease and other neuropsychiatric disorders likely depends on the modulation of neuronal rhythms in the target nuclei. This modulation could be effectively measured with local field potential (LFP) recordings during DBS. However, a technical drawback that prevents LFPs from being recorded from the DBS target nuclei during stimulation is the stimulus artefact. To solve this problem, we designed and developed 'FilterDBS', an electronic amplification system for artefact-free LFP recordings (in the frequency range 2-40 Hz) during DBS. After defining the estimated system requirements for LFP amplification and DBS artefact suppression, we tested the FilterDBS system by conducting experiments in vitro and in vivo in patients with advanced Parkinson's disease undergoing DBS of the subthalamic nucleus (STN). Under both experimental conditions, in vitro and in vivo, the FilterDBS system completely suppressed the DBS artefact without inducing significant spectral distortion. The FilterDBS device pioneers the development of an adaptive DBS system retroacted by LFPs and can be used in novel closed-loop brain-machine interface applications in patients with neurological disorders.
高频深部脑刺激（DBS）对帕金森病和其他神经精神疾病的临床疗效可能取决于对目标核团神经元节律的调节。这种调节可以在DBS期间通过局部场电位（LFP）记录进行有效测量。然而，在刺激过程中阻止从DBS目标核团记录LFP的一个技术缺陷是刺激伪迹。为了解决这个问题，我们设计并开发了“FilterDBS”，这是一种用于在DBS期间进行无伪迹LFP记录（频率范围为2 - 40 Hz）的电子放大系统。在确定了LFP放大和DBS伪迹抑制的估计系统要求后，我们通过在体外和体内对接受丘脑底核（STN）DBS的晚期帕金森病患者进行实验来测试FilterDBS系统。在体外和体内这两种实验条件下，FilterDBS系统都完全抑制了DBS伪迹，且未引起明显的频谱失真。FilterDBS设备开创了由LFP反馈的自适应DBS系统的发展，可用于神经疾病患者的新型闭环脑机接口应用。
