Su Jui-Hsin, Dai Chang-Feng, Huang Hsin-Hui, Wu Yang-Chang, Sung Ping-Jyun, Hsu Chi-Hsin, Sheu Jyh-Horng
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaoshiung, Taiwan, R.O.C.
Chem Pharm Bull (Tokyo). 2007 Apr;55(4):594-7. doi: 10.1248/cpb.55.594.
Two new sesquiterpenoidal natural products chabrolidiones A and B (1 and 2), two C(18) terpenoid-related carboxylic acids, ketochabrolic acid (3) and isoketochabrolic acid (4), and one naphthoquinone derivative chabrolonaphthoquinone C (5), along with two known compounds (+)-aristolone (6) and teuhetenone A (7) were isolated from a Formosan soft coral Nephthea chabrolii. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis and by comparison of NMR data with those of related metabolites. Metabolite 1 has been synthesized previously, but was isolated for the first time from natural sources. Cytotoxic activity of metabolites 1-3 and 5-7 against a limited panel of cancer cell lines is also described.
从台湾软珊瑚中华排孔珊瑚（Nephthea chabrolii）中分离得到了两种新的倍半萜类天然产物查布罗利二酮A和B（1和2）、两种与C(18)萜类相关的羧酸酮查布罗利酸（3）和异酮查布罗利酸（4）、一种萘醌衍生物查布罗萘醌C（5），以及两种已知化合物(+)-亚里士多酮（6）和土海酮A（7）。通过广泛的光谱分析，并将核磁共振数据与相关代谢物的数据进行比较，确定了这些新代谢物的结构。代谢物1之前已被合成，但首次从天然来源中分离得到。还描述了代谢物1 - 3和5 - 7对一组有限癌细胞系的细胞毒性活性。
