Saijo Y, Utsugi M, Yoshioka E, Horikawa N, Sato T, Gong Y Y, Kishi R
Department of Public Heath, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
J Hum Hypertens. 2005 Nov;19(11):907-13. doi: 10.1038/sj.jhh.1001913.
The relationships between C-reactive protein (CRP), uric acid (UA), glomerular filtration rate (GFR), and arterial stiffness have not been fully investigated. The aim of this study was to clarify whether CRP, UA, and estimated GFR are related to arterial stiffness estimated using brachial-ankle pulse wave velocity (baPWV). The subjects were local government employees (3412 men and 854 women). baPWV, CRP, UA, GFR, and conventional risk factors were evaluated. Multiple linear regression analyses revealed that CRP and UA were significantly related to an elevation of PWV in male and female subjects, and that the estimated GFR was significantly related to an elevation of PWV in male subjects. Significant progressive increases in baPWV were observed across the quartiles of CRP in male subjects and for UA in male and female subjects. In female subjects, the relationship of quartile CRP to baPWV had marginal significance (P = 0.055). But, in male and female subjects, quartile of estimated GFR had no significant association with PWV. These results suggest that CRP and UA are associated with an increase of arterial stiffness in male and female subjects, and that estimated GFR is possibly related to arterial stiffness in male subjects.
C反应蛋白（CRP）、尿酸（UA）、肾小球滤过率（GFR）与动脉僵硬度之间的关系尚未得到充分研究。本研究的目的是阐明CRP、UA和估算的GFR是否与使用臂踝脉搏波速度（baPWV）估算的动脉僵硬度相关。研究对象为当地政府雇员（3412名男性和854名女性）。对baPWV、CRP、UA、GFR和传统危险因素进行了评估。多元线性回归分析显示，CRP和UA与男性和女性受试者的PWV升高显著相关，估算的GFR与男性受试者的PWV升高显著相关。在男性受试者中，随着CRP四分位数的增加，baPWV显著逐渐升高；在男性和女性受试者中，随着UA四分位数的增加，baPWV也显著逐渐升高。在女性受试者中，CRP四分位数与baPWV的关系具有边缘显著性（P = 0.055）。但是，在男性和女性受试者中，估算的GFR四分位数与PWV无显著关联。这些结果表明，CRP和UA与男性和女性受试者的动脉僵硬度增加有关，估算的GFR可能与男性受试者的动脉僵硬度有关。
