Yoon Hye Eun, Mo Eun Young, Shin Seok Joon, Moon Sung Dae, Han Je Ho, Kim Eun Sook
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Division of Nephrology, Department of Internal Medicine, Incheon St. Mary's Hospital, Incheon, Republic of Korea.
Cardiovasc Diabetol. 2016 Aug 5;15(1):108. doi: 10.1186/s12933-016-0426-1.
This study investigated the association between serum gamma-glutamyltransferase (GGT) level and subclinical atherosclerosis in patients with type 2 diabetes.
This cross-sectional study involved 1024 patients with type 2 diabetes mellitus. Measurement of brachial-ankle pulse wave velocity (baPWV; as a marker of arterial stiffness) and an ultrasound assessment of carotid atherosclerosis were performed. Subclinical atherosclerosis was defined by the presence of a high baPWV (≥1720 cm/s), carotid atherosclerosis (intima-media thickness >0.8 mm or the presence of plaques), and carotid stenosis (≥50 % of luminal narrowing). The subjects were stratified into quartiles according to GGT level, and the relationship between GGT level and subclinical atherosclerosis was analysed.
Serum GGT levels were closely associated with obesity, atherogenic dyslipidemia, and metabolic syndrome. However, serum GGT levels did not show a linear association with baPWV, carotid intima-media thickness, or plaque grade. The prevalence of high baPWV, carotid atherosclerosis, and carotid stenosis did not differ between the quartiles in men and women. Multivariate logistic regression analyses revealed no association between GGT level and high baPWV, carotid atherosclerosis, and carotid stenosis, either as continuous variables or quartiles.
Serum GGT levels were significantly associated with obesity, atherogenic dyslipidaemia, and metabolic syndrome, but not with the early and late stages of atherosclerotic vascular changes, in patients with type 2 diabetes. Serum GGT level may not be a reliable marker of subclinical atherosclerosis in type 2 diabetes.
本研究调查了2型糖尿病患者血清γ-谷氨酰转移酶（GGT）水平与亚临床动脉粥样硬化之间的关联。
这项横断面研究纳入了1024例2型糖尿病患者。测量肱踝脉搏波速度（baPWV；作为动脉僵硬度的指标）并进行颈动脉粥样硬化的超声评估。亚临床动脉粥样硬化的定义为高baPWV（≥1720 cm/s）、颈动脉粥样硬化（内膜中层厚度>0.8 mm或存在斑块）以及颈动脉狭窄（管腔狭窄≥50%）。根据GGT水平将受试者分为四分位数，并分析GGT水平与亚临床动脉粥样硬化之间的关系。
血清GGT水平与肥胖、致动脉粥样硬化血脂异常和代谢综合征密切相关。然而，血清GGT水平与baPWV、颈动脉内膜中层厚度或斑块分级之间未显示出线性关联。男性和女性四分位数组之间高baPWV、颈动脉粥样硬化和颈动脉狭窄的患病率没有差异。多因素逻辑回归分析显示，无论是作为连续变量还是四分位数，GGT水平与高baPWV、颈动脉粥样硬化和颈动脉狭窄之间均无关联。
在2型糖尿病患者中，血清GGT水平与肥胖、致动脉粥样硬化血脂异常和代谢综合征显著相关，但与动脉粥样硬化血管变化的早期和晚期无关。血清GGT水平可能不是2型糖尿病亚临床动脉粥样硬化的可靠标志物。
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