Van Doorslaer Koenraad, Rector Annabel, Jenson A Bennett, Sundberg John P, Van Ranst Marc, Ghim Shin-Je
Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Belgium.
The James Graham Brown Cancer Center, University of Louisville, KY, USA.
J Gen Virol. 2007 May;88(Pt 5):1484-1488. doi: 10.1099/vir.0.82615-0.
The papillomaviruses form a large group of species-specific pathogens that cause epithelial proliferations in a wide spectrum of animal hosts. Previous reports demonstrated a relatively high frequency of a variety of skin lesions in captive European harvest mice. The Micromys minutus papillomavirus (MmPV) was isolated from one of these lesions found on a captive European harvest mouse in a regional zoo in Chicago. In this study we present the entire genomic sequence of MmPV. The MmPV genome is organized into the seven classical papillomaviral open reading frames. Phylogenetic analysis places MmPV together with a papillomavirus (PV) isolated from a Syrian golden Hamster (HaOPV) in the genus Pipapillomavirus. The similar clustering pattern of the MmPV-HaOPV pair and their rodent hosts support the hypothesis of papillomaviral and host co-phylogenetic descent. The availability of the complete genomic sequence of a mouse PV should allow researchers to use MmPV as a model for PV carcinogenesis.
乳头瘤病毒构成了一大类物种特异性病原体，可在多种动物宿主中引起上皮细胞增殖。先前的报告显示，圈养的欧洲收获鼠中各种皮肤病变的发生率相对较高。微小鼠乳头瘤病毒（MmPV）是从芝加哥地区动物园一只圈养的欧洲收获鼠身上发现的其中一种病变中分离出来的。在本研究中，我们展示了MmPV的完整基因组序列。MmPV基因组被组织成七个经典的乳头瘤病毒开放阅读框。系统发育分析将MmPV与从叙利亚金仓鼠分离出的一种乳头瘤病毒（PV）（HaOPV）归为 Pipapillomavirus 属。MmPV-HaOPV 对及其啮齿动物宿主的相似聚类模式支持了乳头瘤病毒和宿主共同系统发育起源的假说。小鼠PV完整基因组序列的可得性应使研究人员能够将MmPV用作PV致癌作用的模型。
