Feng Jian, Fouse Shaun, Fan Guoping
Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA.
Pediatr Res. 2007 May;61(5 Pt 2):58R-63R. doi: 10.1203/pdr.0b013e3180457635.
The development and function of the CNS requires accurate gene transcription control in response to proper environmental signals. Epigenetic mechanisms, including DNA methylation, histone modifications, and other chromatin-remodeling events, are critically important in mediating precise neural gene regulation. This review focuses on discussing the role of DNA methylation and histone modifications in neural lineage differentiation, synaptic plasticity and neural behavior. We postulate that DNA methylation- and histone modification-mediated gene regulation is not only important for neural cell differentiation but also crucial for high-order cognitive functions such as learning and memory.
中枢神经系统的发育和功能需要根据适当的环境信号进行精确的基因转录控制。表观遗传机制，包括DNA甲基化、组蛋白修饰和其他染色质重塑事件，在介导精确的神经基因调控中至关重要。本综述着重讨论DNA甲基化和组蛋白修饰在神经谱系分化、突触可塑性和神经行为中的作用。我们推测，DNA甲基化和组蛋白修饰介导的基因调控不仅对神经细胞分化很重要，而且对诸如学习和记忆等高阶认知功能也至关重要。
