Saetrom Pål, Snøve Ola, Rossi John J
Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Pediatr Res. 2007 May;61(5 Pt 2):17R-23R. doi: 10.1203/pdr.0b013e318045760e.
MicroRNAs (miRNAs) regulate protein-coding genes post transcriptionally in higher eukaryotes. Argonaute proteins are important in miRNA regulation and are also implicated in epigenetic mechanisms such as histone modifications and DNA methylation. Here, we review miRNA regulation and outline its connections to epigenetics.
微小RNA(miRNA)在高等真核生物中对蛋白质编码基因进行转录后调控。AGO蛋白在miRNA调控中起重要作用,并且还参与表观遗传机制,如组蛋白修饰和DNA甲基化。在此,我们综述miRNA调控并概述其与表观遗传学的联系。