Fayad Jose N, Schwartz Marc S, Slattery William H, Brackmann Derald E
House Clinic and House Ear Institute, Los Angeles, California 90057, USA.
Otol Neurotol. 2007 Apr;28(3):387-90. doi: 10.1097/01.mao.0000265188.22345.d4.
To determine the incidence rate of cerebrospinal fluid (CSF) leak after translabyrinthine acoustic tumor removal using titanium mesh cranioplasty and to compare with previous series and historical controls.
Database analysis with historical controls.
Tertiary referral neurotologic private practice.
The series of 389 patients who underwent titanium mesh cranioplasty after translabyrinthine tumor removal between March 2003 and July 2005. The results were compared with those in a group of 1,195 translabyrinthine tumor removal patients from our previously published series and with those in a group of 324 patients from the immediately preceding two-year period.
Cranioplasty using titanium mesh after acoustic tumor removal.
Rates of CSF leak for this method and previous methods of closure.
Thirteen patients (3.3%) had CSF leaks when using the new method of titanium mesh closure. This compares with rates of 10.9% and 8.7% in series in which other methods of closure were used (p < 0.001 and 0.003). The rates of CSF leak requiring reoperation were 0.5%, 2.5%, and 1.9% for the new and the two older series, respectively.
In our hands, titanium mesh cranioplasty seems to reduce the rate of CSF leaks after the translabyrinthine removal of acoustic tumors.
确定使用钛网颅骨成形术进行经迷路听神经瘤切除术后脑脊液漏的发生率，并与既往系列研究及历史对照进行比较。
采用历史对照的数据库分析。
三级转诊神经耳科私人诊所。
2003年3月至2005年7月间389例行经迷路肿瘤切除术后接受钛网颅骨成形术的患者。将结果与我们之前发表的系列研究中的1195例经迷路肿瘤切除患者以及前两年的324例患者进行比较。
听神经瘤切除术后使用钛网进行颅骨成形术。
该方法及既往闭合方法的脑脊液漏发生率。
采用钛网新闭合方法时，13例患者（3.3%）发生脑脊液漏。与之相比，采用其他闭合方法的系列研究中脑脊液漏发生率分别为10.9%和8.7%（p < 0.001和0.003）。新系列及两个旧系列中因脑脊液漏需要再次手术的发生率分别为0.5%、2.5%和1.9%。
在我们的研究中，钛网颅骨成形术似乎可降低经迷路切除听神经瘤后脑脊液漏的发生率。
