Heinemann Falko M, Rebmann Vera, Witzke Oliver, Philipp Thomas, Broelsch Christoph E, Grosse-Wilde Hans
Institut für Immunologie, Universitätsklinikum Essen, Essen, Germany.
Transplantation. 2007 Mar 27;83(6):706-11. doi: 10.1097/01.tp.0000255326.27474.a4.
Recent reports suggest that high pretransplant serum levels of soluble CD30 (sCD30) are a risk factor for rejections after kidney transplantation. The aim of our study was to elucidate the predictive value of pretransplant sCD30 levels for kidney transplantation outcome in a single-center patient cohort that has been treated with modern immunosuppressive therapies after transplantation.
We retrospectively analyzed sCD30 in multiple pretransplant sera from 206 patients, of whom 174 were transplanted with a cadaveric kidney and 32 patients received an allograft from a living donor. Renal function after transplantation was estimated by measuring serum creatinine and by rejection diagnosis.
We could demonstrate a statistically significant association between increased pretransplant sCD30 values and graft failures (P=0.005). Receiver operating curve analysis revealed a cutoff value of 124 U/mL pretransplant sCD30. A multivariate analysis confirmed pretransplant sCD30 values >124 U/mL (P=0.011) and rejection episodes (P<0.0001) as independent risk factors for graft loss.
Our study revealed a strong correlation between pretransplant sCD30 levels and the incidence of graft failure, but we could not confirm that the development of rejection episodes is correlated with pretransplant sCD30 values.
近期报告表明，移植前血清中可溶性CD30（sCD30）水平升高是肾移植后发生排斥反应的一个危险因素。我们研究的目的是在一个单中心患者队列中阐明移植前sCD30水平对肾移植结局的预测价值，该队列在移植后接受了现代免疫抑制治疗。
我们回顾性分析了206例患者多个移植前血清中的sCD30，其中174例接受了尸体肾移植，32例患者接受了活体供者的同种异体肾移植。通过测量血清肌酐和诊断排斥反应来评估移植后的肾功能。
我们能够证明移植前sCD30值升高与移植失败之间存在统计学上的显著关联（P = 0.005）。受试者工作特征曲线分析显示移植前sCD30的临界值为124 U/mL。多变量分析证实移植前sCD30值>124 U/mL（P = 0.011）和排斥反应发作（P<0.0001）是移植失败的独立危险因素。
我们的研究揭示了移植前sCD30水平与移植失败发生率之间存在密切相关性，但我们无法证实排斥反应发作的发生与移植前sCD30值相关。
