Milleron B J, Costabel U, Teschler H, Ziesche R, Cadranel J L, Matthys H, Akoun G M
Centre de Pneumologie et de Réanimation Respiratoire, Hôpital Tenon, Paris, France.
Am Rev Respir Dis. 1991 Dec;144(6):1330-2. doi: 10.1164/ajrccm/144.6.1330.
In bronchoalveolar lavage fluid (BAL) from nine patients with alveolar proteinosis (AP), total and differential cell count and T-lymphocyte phenotyping were done and compared with those in 12 healthy volunteers comparable as to age and tobacco consumption. Although total cell count was not significantly different from that in control subjects, the most prominent feature in patients was an increase in the number of CD4 and CD8 T-lymphocytes within the alveoli. Conversely, the macrophage population was significantly reduced. The ratio of CD4/CD8 T-lymphocytes tended to be high, but this increase did not reach statistical significance. The pathophysiologic mechanism and the meaning of these alveolar cell changes in AP remain to be elucidated.
对9例肺泡蛋白沉积症（AP）患者的支气管肺泡灌洗（BAL）液进行了细胞总数、分类计数及T淋巴细胞表型分析，并与12名年龄及吸烟量与之匹配的健康志愿者进行了比较。尽管患者的细胞总数与对照组相比无显著差异，但患者最显著的特征是肺泡内CD4和CD8 T淋巴细胞数量增加。相反，巨噬细胞数量显著减少。CD4/CD8 T淋巴细胞比值有升高趋势，但这种升高未达到统计学意义。AP中这些肺泡细胞变化的病理生理机制及意义仍有待阐明。
