Setoguchi Y, Takahashi S, Nukiwa T, Kira S
Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo, Japan.
Am Rev Respir Dis. 1991 Dec;144(6):1361-5. doi: 10.1164/ajrccm/144.6.1361.
Lymphocytic interstitial pneumonia (LIP) is a rare form of interstitial pneumonia with infiltration of mononuclear cells in the interstitium, the pathogenesis of which is unknown. We studied six patients with LIP to investigate the immunologic characteristics of lymphocytes in the lower respiratory tract and the possible involvement of human T-cell lymphotropic virus type I (HTLV-I), which is endemic in the southwestern region of Japan. Lymphocyte surface antigen phenotyping in peripheral blood (PB) and bronchoalveolar lavage fluid (BALF) cells revealed a predominance of CD8 positive (suppressor/cytotoxic) T-lymphocytes (PB: 51.5 +/- 0.8%; BALF: 52.9 +/- 12.7%), which consisted of an increased number of CD8 positive CD11 negative (cytotoxic) T-lymphocytes (PB: 30.2 +/- 10.5%; BALF: 57.1 +/- 11.8%). The increased number of cytotoxic T-lymphocytes among patients with LIP led us to investigate the possible involvement of HTLV-I, EB virus, and HIV in patients with chronic interstitial disorders of LIP, sarcoidosis, and IPF. The seropositivity rate for HTLV-I was 83.7% (5/6) in patients with LIP, 3.1% (1/28) with IPF, 7.1% (2/28) with sarcoidosis, and 0% (0/28) in healthy volunteers. None of the patients were seropositive for either HIV or EB virus. These results suggest that HTLV-I may be involved in a direct or indirect role in the pathologic mechanisms through the host immune reaction to the antigenicity of the virus and/or the possible involvement of viral regulatory genes to disrupt the normal immune reaction of the host.
淋巴细胞间质性肺炎（LIP）是一种罕见的间质性肺炎，其特征为间质内单核细胞浸润，发病机制不明。我们研究了6例LIP患者，以探讨下呼吸道淋巴细胞的免疫特征以及日本西南部地区流行的I型人类嗜T淋巴细胞病毒（HTLV-I）的可能参与情况。外周血（PB）和支气管肺泡灌洗液（BALF）细胞的淋巴细胞表面抗原表型分析显示，CD8阳性（抑制/细胞毒性）T淋巴细胞占优势（PB：51.5±0.8%；BALF：52.9±12.7%），其中CD8阳性CD11阴性（细胞毒性）T淋巴细胞数量增加（PB：30.2±10.5%；BALF：57.1±11.8%）。LIP患者中细胞毒性T淋巴细胞数量的增加促使我们研究HTLV-I、EB病毒和HIV在LIP、结节病和特发性肺纤维化（IPF）等慢性间质性疾病患者中的可能参与情况。LIP患者中HTLV-I血清阳性率为83.7%（5/6），IPF患者为3.1%（1/28），结节病患者为7.1%（2/28），健康志愿者为0%（0/28）。所有患者HIV和EB病毒血清均为阴性。这些结果表明，HTLV-I可能通过宿主对病毒抗原性的免疫反应在病理机制中直接或间接发挥作用，和/或病毒调控基因可能参与破坏宿主的正常免疫反应。
