Goto K, Saeki K, Kurita M, Iijima Y, Miyake A, Ohno S
Division of Ophthalmology, Odawara Municipal Hospital, Japan.
Jpn J Ophthalmol. 1994;38(2):175-7.
Recently, human T-lymphotropic virus type I (HTLV-I) has been shown to cause endogenous uveitis, HTLV-I associated uveitis. To investigate the association of hereditary or environmental factors with the incidence of this uveitis, HTLV-I seroprevalence was studied in patients with undefined uveitis in central Japan, where HTLV-I infection has not been considered highly endemic. Of 129 patients with undefined uveitis, 6 (4.6%) were seropositive, and 4 of these 6 seropositive cases with undefined uveitis were born in southwestern Japan, where HTLV-I infection is highly endemic. As regards the incidence rate of uveitis, 4 of 9 (44.4%) seropositive cases from southwestern Japan developed uveitis, whereas only 2 of 21 (9.5%) seropositive cases from central Japan developed uveitis. The difference was statistically significant (P < 0.05). This results suggests that the incidence of HTLV-I associated uveitis could be influenced by environmental or hereditary factors including HLA.
最近，已证实人类嗜T淋巴细胞病毒I型（HTLV-I）可引起内因性葡萄膜炎，即HTLV-I相关性葡萄膜炎。为了研究遗传或环境因素与这种葡萄膜炎发病率之间的关联，我们对日本中部葡萄膜炎病因不明的患者进行了HTLV-I血清阳性率研究，在该地区HTLV-I感染未被视为高流行情况。在129例葡萄膜炎病因不明的患者中，6例（4.6%）血清呈阳性，这6例血清阳性且葡萄膜炎病因不明的患者中有4例出生于日本西南部，该地区HTLV-I感染呈高流行。关于葡萄膜炎的发病率，来自日本西南部的9例血清阳性病例中有4例（44.4%）患了葡萄膜炎，而来自日本中部的21例血清阳性病例中只有2例（9.5%）患了葡萄膜炎。差异具有统计学意义（P<0.05）。这一结果表明，HTLV-I相关性葡萄膜炎的发病率可能受包括HLA在内的环境或遗传因素影响。
