Townsend Raymond R
University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Curr Opin Nephrol Hypertens. 2007 May;16(3):261-6. doi: 10.1097/MNH.0b013e328042baa4.
The use of peripheral pressure wave recording devices to estimate central vessel pressure profiles has grown over the past decade. This review will briefly recount the history behind this technology and discuss where it fits into the measurement of vascular properties that may predict outcomes such as death, heart attack, stroke or kidney disease progression.
Recent cross-sectional studies involving both children with chronic kidney disease and adult patients with cardiovascular disease are reviewed. Importantly there are now at least three prospective series that indicate pulse wave analysis technology may be useful both for endpoint prediction (complementing blood pressure and other standard vascular risk factors) and for informing mechanisms of benefit when clinical trials with similar blood pressure control have discordant outcomes depending on the drug assignment.
Pulse wave analysis is an interesting technology with the plausible benefit of estimating central vascular pressures. Since the principal target organs we seek to protect with our treatments are all connected to the aorta, it may be that a better understanding of target organ risk from an aortic as opposed to a brachial standpoint will help move forward our interventions to reduce vascular disease.
在过去十年中，使用外周压力波记录设备来估计中心血管压力曲线的情况日益增多。本综述将简要回顾这项技术背后的历史，并讨论其在血管特性测量中的作用，这些血管特性可能预测诸如死亡、心脏病发作、中风或肾脏疾病进展等结果。
对近期涉及慢性肾病儿童和心血管疾病成年患者的横断面研究进行了综述。重要的是，现在至少有三个前瞻性系列研究表明，脉搏波分析技术可能不仅有助于终点预测（补充血压和其他标准血管危险因素），而且在血压控制相似的临床试验根据药物分配产生不一致结果时，有助于阐明获益机制。
脉搏波分析是一项有趣的技术，具有估计中心血管压力的潜在益处。由于我们试图通过治疗来保护的主要靶器官都与主动脉相连，从主动脉而非肱动脉的角度更好地理解靶器官风险，可能有助于推动我们减少血管疾病的干预措施。
