Bakris George L, Ritz Eberhard
Hypertensive Diseases Unit, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
J Clin Hypertens (Greenwich). 2009 Mar;11(3):144-7. doi: 10.1111/j.1751-7176.2009.00092.x.
The prevalence of chronic kidney disease (CKD) continues to increase worldwide as does end stage renal disease. The most common, but not only, causes of CKD are hypertension and diabetes. CKD is associated with a significant increase in cardiovascular (CV) risk as most patients with CKD die of a CV cause. Moreover, CV risk increases proportionally as estimated glomerular filtration rate falls below 60 mL/min. CV causes of death in CKD are more prevalent than those from cancer; as a result, the identification and reduction of CKD is a public health priority. High blood pressure is a key pathogenic factor that contributes to the deterioration of kidney function. The presence of kidney disease is a common and underappreciated preexisting medical cause of resistant hypertension. Therefore, treatment of hypertension has become the most important intervention in the management of all forms of CKD. For this reason, World Kidney Day on March 12, 2009 will emphasize the role of hypertension.
慢性肾脏病(CKD)在全球范围内的患病率持续上升,终末期肾病亦是如此。CKD最常见(但并非唯一)的病因是高血压和糖尿病。CKD与心血管(CV)风险的显著增加相关,因为大多数CKD患者死于心血管疾病。此外,随着估计肾小球滤过率降至60 mL/分钟以下,心血管风险成比例增加。CKD患者因心血管疾病导致的死亡比癌症更为普遍;因此,识别和减少CKD是公共卫生的优先事项。高血压是导致肾功能恶化的关键致病因素。肾病的存在是难治性高血压常见且未得到充分认识的既往医学病因。因此,高血压治疗已成为各种形式CKD管理中最重要的干预措施。出于这个原因,2009年3月12日的世界肾脏日将强调高血压的作用。