Lai Michael M, Williams George A
Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, Michigan 48073, USA.
Retina. 2007 Apr-May;27(4):477-82. doi: 10.1097/01.iae.0000247166.11120.21.
To report the anatomical, visual, and optical coherence tomography (OCT) results of using a brief application of a low concentration of indocyanine green (ICG) to assist the removal of internal limiting membrane (ILM) during idiopathic macular hole repair.
Retrospective, interventional, noncomparative case series of 59 eyes of 57 patients with stage 2, 3, or 4 idiopathic macular holes who underwent pars plana vitrectomy with removal of ILM assisted by a brief (<30 seconds) intravitreal application of 0.125% (1.25 mg/mL) ICG.
The median follow-up period was 13 months (range, 2-40 months). Anatomical closure of the macular hole was achieved in 58 eyes (98%) with a single surgery. Visual acuity improved from a preoperative mean of 20/100 to 20/60 postoperatively (P < 0.0001). Twenty-nine eyes (49%) had postoperative visual acuity of 20/50 or better. Visual acuity improved by > or =2 lines in 43 eyes (73%) and between 0 and 2 lines in 13 eyes (22%) and decreased in 3 eyes (5%). Postoperative OCT showed closure of macular hole with normal foveal depression in 49 (89%) of 55 eyes.
A brief application of ICG at a low concentration appears to provide a safe and effective way of assisting ILM peeling during idiopathic macular hole surgery.
报告在特发性黄斑裂孔修复术中使用低浓度吲哚菁绿（ICG）短暂应用辅助内界膜（ILM）切除的解剖学、视觉及光学相干断层扫描（OCT）结果。
对57例患有2、3或4期特发性黄斑裂孔的患者的59只眼进行回顾性、介入性、非对照病例系列研究，这些患者接受了经平坦部玻璃体切除术，并在玻璃体腔内短暂（<30秒）应用0.125%（1.25mg/mL）ICG辅助切除ILM。
中位随访期为13个月（范围2 - 40个月）。58只眼（98%）通过单次手术实现了黄斑裂孔的解剖学闭合。视力从术前平均20/100提高到术后20/60（P < 0.0001）。29只眼（49%）术后视力达到20/50或更好。43只眼（73%）视力提高≥2行，13只眼（22%）视力提高0至2行，3只眼（5%）视力下降。术后OCT显示55只眼中49只（89%）黄斑裂孔闭合且中央凹正常凹陷。
低浓度ICG的短暂应用似乎为特发性黄斑裂孔手术中辅助ILM剥除提供了一种安全有效的方法。
