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[诱发电位在重型颅脑损伤后昏迷患者随访及预后评估中的应用]

[The use of evoked potentials in the follow-up and prognosis of patients in coma following severe traumatic brain injury].

作者信息

González-García E, Vilela-Soler C, Romá-Ambrosio J, Fenollosa-Entrena B

机构信息

Servicio de Neurofisiología Clínica, Hospital Universitari La Fe, Universitat de Valéncia, 46009 Valencia, España.

出版信息

Rev Neurol. 2007;44(7):404-10.

Abstract

INTRODUCTION

When dealing with patients in coma, it can be very useful to have early access to objective tests that provide information about their clinical status and can help to establish a prognosis for survival and functional recovery. The value of evoked potentials (EP) in such cases is already well known, although only techniques that assess the neurological status have been used.

AIM

To determine the usefulness of different types of evoked potentials as a means of reaching a short and medium term prognosis for survival and functional recovery in patients in coma as a result of traumatic brain injury (TBI).

PATIENTS AND METHODS

Our study involved patients with an admission Glasgow coma score of 8 or below due to severe TBI. During the first 24 hours the following tests were carried out on patients: somatosensory EP (SSEP), brainstem auditory EP, visual EP (VEP) obtained using stimulation goggles and mismatch negativity, as well as an imaging test (computerised axial tomography). The tests were repeated at one week and one month, and each patient was evaluated by means of the Glasgow scale and the Karnofsky scale.

RESULTS

We studied 22 patients (mean age: 39.95 years; interval: 15-84 years), 20 of them were males. The highest number of deaths occurred during the first week. There was a strong correlation between survival and the results from the SSEP and VEP.

CONCLUSIONS

SSEP and VEP performed on admission were a valuable aid for reaching a short and medium term prognosis for survival of patients in coma due to TBI, although they were not effective in evaluating a prognosis for functional recovery.

摘要

引言

在处理昏迷患者时,能够尽早进行客观测试以获取有关其临床状况的信息,并有助于确定生存和功能恢复的预后,这非常有用。诱发电位(EP)在这类病例中的价值已广为人知,不过此前仅使用了评估神经状态的技术。

目的

确定不同类型的诱发电位作为预测因创伤性脑损伤(TBI)导致昏迷的患者短期和中期生存及功能恢复预后的手段的有效性。

患者与方法

我们的研究纳入了因严重TBI入院时格拉斯哥昏迷评分在8分及以下的患者。在最初24小时内,对患者进行了以下测试:体感诱发电位(SSEP)、脑干听觉诱发电位、使用刺激眼罩获得的视觉诱发电位(VEP)以及失配负波,还有一项影像学检查(计算机断层扫描)。在一周和一个月时重复进行这些测试,并且通过格拉斯哥量表和卡诺夫斯基量表对每位患者进行评估。

结果

我们研究了22例患者(平均年龄:39.95岁;范围:15 - 84岁),其中20例为男性。死亡人数最多的情况发生在第一周。生存与SSEP和VEP的结果之间存在很强的相关性。

结论

入院时进行的SSEP和VEP对于预测因TBI导致昏迷的患者短期和中期生存预后是有价值的辅助手段,尽管它们在评估功能恢复预后方面并不有效。

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