Division of Otorhinolaryngology, Hospital das Clinicas, Medical School, University of São Paulo, São Paulo, Brazil.
Am J Rhinol Allergy. 2010 May-Jun;24(3):210-4. doi: 10.2500/ajra.2010.24.3467.
Contact endoscopy (CE) was initially described as a method used in the analysis of uterine and vocal folds histology. The first nasal cavity CE studies achieved promising results regarding its use for the differentiation between benign and malignant lesions, considering that biopsy might cause some complications, especially bleeding. This study described and compared the findings of CE on inverted papilloma and nasosinusal squamous cell carcinoma (SCC) and tested the effectiveness of this exam as a noninvasive method for in vivo differentiation between these tumors.
The patients included in this study were divided into group A, patients diagnosed with inverted papilloma, and group B, patients diagnosed with SCC. CE results were compared among themselves. CE images were presented to examiners not experienced with the method.
Twenty-two patients were examined, 13 in group A and 9 in group B. The main relevant differences in CE findings between those two groups were corkscrew vessels, presence of mitoses, keratinization and nuclear pleomorphism in carcinoma, and vacuolated cells in papilloma. The examiners were capable of defining the diagnosis of these nasal tumors only based on CE images.
CE may be a useful noninvasive exam to be used in the in vivo diagnosis of inverted papilloma and nasosinusal SCC, which may enable better preoperative planning.
接触内镜（CE）最初被描述为一种用于分析子宫和声带组织学的方法。最初的鼻腔 CE 研究在区分良性和恶性病变方面取得了有希望的结果，因为活检可能会引起一些并发症，尤其是出血。本研究描述并比较了 CE 在 inverted papilloma 和 nasosinusal squamous cell carcinoma（SCC）中的发现，并测试了该检查作为一种非侵入性方法在活体中区分这些肿瘤的有效性。
本研究将患者分为 A 组（诊断为 inverted papilloma 的患者）和 B 组（诊断为 SCC 的患者）。比较了组内的 CE 结果。将 CE 图像呈现给不熟悉该方法的检查者。
共检查了 22 例患者，其中 A 组 13 例，B 组 9 例。这两组之间 CE 结果的主要相关差异是旋塞状血管、有丝分裂、角化和核多形性在癌中，以及乳头状瘤中的空泡细胞。检查者仅根据 CE 图像就能确定这些鼻腔肿瘤的诊断。
CE 可能是一种有用的非侵入性检查方法，可用于 inverted papilloma 和 nasosinusal SCC 的活体诊断，从而可以更好地进行术前规划。
