• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从海洋来源放线菌Z(2)039-2中分离得到的两种具有凋亡活性的吲哚咔唑生物碱。

Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2.

作者信息

Liu Rui, Zhu Tianjiao, Li Dehai, Gu Jingyan, Xia Wei, Fang Yuchun, Zhu Weiming, Gu Qianqun

机构信息

Key laboratory of Marine Drugs, Chinese Ministry of Education, Qingdao 266003, PR China.

出版信息

Arch Pharm Res. 2007 Mar;30(3):270-4. doi: 10.1007/BF02977605.

DOI:10.1007/BF02977605
PMID:17424930
Abstract

Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marine-derived actinomycete Z(2)039-2 led to the isolation of two known indolocarbazole alkaloids, K252c (1) and arcyriaflavin A (2). 1 and 2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic activities at 10 and 100 microM, respectively. This is the first report on the significant apoptosis inducing effect of indolocarbazole alkaloids against K562 cancer cells.

摘要

对一株海洋来源放线菌Z(2)039-2发酵液的乙酸乙酯提取物进行生物活性导向的分离，得到了两种已知的吲哚咔唑生物碱，K252c（1）和刺孢黄素A（2）。化合物1和2对K562细胞系表现出中等细胞毒性活性，并分别在10和100微摩尔浓度下诱导凋亡活性。这是关于吲哚咔唑生物碱对K562癌细胞具有显著凋亡诱导作用的首次报道。

相似文献

1
Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2.从海洋来源放线菌Z(2)039-2中分离得到的两种具有凋亡活性的吲哚咔唑生物碱。
Arch Pharm Res. 2007 Mar;30(3):270-4. doi: 10.1007/BF02977605.
2
4'-N-methyl-5'-hydroxystaurosporine and 5'-hydroxystaurosporine, new indolocarbazole alkaloids from a marine Micromonospora sp. strain.4'-N-甲基-5'-羟基星孢菌素和5'-羟基星孢菌素，来自海洋小单孢菌属菌株的新型吲哚咔唑生物碱。
J Antibiot (Tokyo). 2000 Sep;53(9):895-902. doi: 10.7164/antibiotics.53.895.
3
Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana.克劳赖拉 A-D，从胡桐根源生的细胞毒素咔唑生物碱。
J Nat Prod. 2011 Feb 25;74(2):208-12. doi: 10.1021/np100654m. Epub 2011 Feb 8.
4
Glycosmisines A and B: isolation of two new carbazole-indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities.九里香素A和B：从五指毛九里香中分离出两种新型咔唑-吲哚型二聚体生物碱并评估其抗增殖活性。
Org Biomol Chem. 2015 Jun 28;13(24):6773-81. doi: 10.1039/c5ob00695c.
5
One new indolocarbazole alkaloid from the Streptomyces sp. A22.从链霉菌属A22中分离得到的一种新的吲哚咔唑生物碱。
Nat Prod Res. 2018 Nov;32(21):2583-2588. doi: 10.1080/14786419.2018.1428595. Epub 2018 Jan 22.
6
Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities.来自山地山小橘的具有弱抗HIV和细胞毒性活性的吲哚和咔唑生物碱。
Phytochemistry. 2005 Mar;66(6):697-701. doi: 10.1016/j.phytochem.2005.02.003.
7
Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823.阿西瑞黄素E，一种通过含分枝菌酸细菌与肉桂色链霉菌NBRC 13823联合培养分离得到的新型细胞毒性吲哚咔唑生物碱。
J Antibiot (Tokyo). 2015 May;68(5):342-4. doi: 10.1038/ja.2014.147. Epub 2014 Oct 22.
8
Carbazole alkaloids from Clausena hainanensis with their potential antiproliferative activities.海南蒌叶中的咔唑生物碱及其潜在的抗增殖活性。
Bioorg Chem. 2018 Feb;76:359-364. doi: 10.1016/j.bioorg.2017.12.016. Epub 2017 Dec 5.
9
Bioactive carbazole alkaloids from Clausena wallichii roots.武靴藤根中的生物活性咔唑生物碱。
J Nat Prod. 2012 Apr 27;75(4):741-6. doi: 10.1021/np3000365. Epub 2012 Apr 6.
10
Bioactive dimeric carbazole alkaloids from Murraya koenigii.从九里香中分离得到的具有生物活性的二聚咔唑生物碱。
J Nat Prod. 2013 Jun 28;76(6):993-1000. doi: 10.1021/np300464t. Epub 2013 May 21.

引用本文的文献

1
Synergistic Anticancer Effect of a Combination of Berbamine and Arcyriaflavin A against Glioblastoma Stem-like Cells.贝母素甲和石耳黄素 A 联合对神经胶质瘤干细胞的协同抗癌作用。
Molecules. 2022 Nov 17;27(22):7968. doi: 10.3390/molecules27227968.
2
Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review.放线菌来源的天然产物作为抗结直肠癌新疗法的潜在来源：综述
Front Pharmacol. 2022 Jul 11;13:929161. doi: 10.3389/fphar.2022.929161. eCollection 2022.
3
Antimicrobial Activity and Functional Genes of Actinobacteria from Coastal Wetland.
沿海湿地放线菌的抗菌活性及功能基因
Curr Microbiol. 2021 Aug;78(8):3058-3067. doi: 10.1007/s00284-021-02560-3. Epub 2021 Jun 22.
4
Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research.来自海洋放线菌的抗血管生成分子以及斑马鱼模型在癌症研究中的重要性。
Heliyon. 2020 Dec 7;6(12):e05662. doi: 10.1016/j.heliyon.2020.e05662. eCollection 2020 Dec.
5
Anticancer potential of metabolic compounds from marine actinomycetes isolated from Lagos Lagoon sediment.从拉各斯泻湖沉积物中分离出的海洋放线菌代谢化合物的抗癌潜力
J Pharm Anal. 2019 Jun;9(3):201-208. doi: 10.1016/j.jpha.2019.03.004. Epub 2019 Mar 14.
6
Marine Bacterial Compounds Evaluated by In Silico Studies as Antipsychotic Drugs Against Schizophrenia.海洋细菌化合物通过计算机研究评估为治疗精神分裂症的抗精神病药物。
Mar Biotechnol (NY). 2018 Oct;20(5):639-653. doi: 10.1007/s10126-018-9835-3. Epub 2018 Jul 18.
7
Arcyriaflavin a, a cyclin D1-cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis.刺盘孢黄素a，一种细胞周期蛋白D1-细胞周期蛋白依赖性激酶4抑制剂，可诱导人子宫内膜异位症间质细胞凋亡并抑制其增殖：一种子宫内膜异位症的潜在治疗药物。
Reprod Biol Endocrinol. 2017 Jul 18;15(1):53. doi: 10.1186/s12958-017-0272-3.
8
Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107.奥斯特利德S-U，源自海绵真菌金黄色曲霉HDN14-107的新型半萜类化合物。
Mar Drugs. 2016 Jul 14;14(7):131. doi: 10.3390/md14070131.
9
Marine natural products as breast cancer resistance protein inhibitors.海洋天然产物作为乳腺癌耐药蛋白抑制剂
Mar Drugs. 2015 Apr 3;13(4):2010-29. doi: 10.3390/md13042010.
10
Expansion of bisindole biosynthetic pathways by combinatorial construction.通过组合构建扩展双吲哚生物合成途径。
ACS Synth Biol. 2015 Jun 19;4(6):682-8. doi: 10.1021/sb5003218. Epub 2015 Jan 2.