Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand.
J Nat Prod. 2012 Apr 27;75(4):741-6. doi: 10.1021/np3000365. Epub 2012 Apr 6.
Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 μg/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC(50) values of 10.2 and 4.5 μM, respectively.
从黄皮 Clausena wallichii 的根部分离得到了四个新的咔唑生物碱，分别为克劳森瓦林 C-F（1-4），以及 18 个已知化合物（5-22）。化合物 3、9 和 22 对耐甲氧西林金黄色葡萄球菌 SK1（MRSA SK1）和金黄色葡萄球菌 TISTR 1466 具有显著的抗菌活性，MIC 值在 4-16μg/mL 范围内，而化合物 4 对口腔癌（KB）和小细胞肺癌（NCI-H187）的细胞毒性最高，IC50 值分别为 10.2 和 4.5μM。
