积雪草苷C2官能团的修饰及其保肝作用评价
Modification of C2 functional group on asiatic acid and the evaluation of hepatoprotective effects.
作者信息
Jeong Byeong-Seon, Lee Mi Kyeong, Kim Young Choong, Lee Eung-Seok
机构信息
College of Pharmacy, Yeungnam University, Kyongsan 712-749, Korea.
出版信息
Arch Pharm Res. 2007 Mar;30(3):282-9. doi: 10.1007/BF02977607.
PMID:17424932
Abstract
For the development of novel hepatoprotective agents, C2 functional group on asiatic acid was modified, and evaluated for their hepatoprotective effects. Among prepared compounds, compounds 10 and 14 showed better hepatoprotective effects compared to silymarin.
摘要
为了开发新型保肝剂，对积雪草苷上的C2官能团进行了修饰，并评估了它们的保肝作用。在所制备的化合物中，化合物10和14与水飞蓟宾相比显示出更好的保肝作用。
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