Yan Shi Fang, Barile Gaetano R, D'Agati Vivette, Du Yan Shi, Ramasamy Ravichandran, Schmidt Ann Marie
Division of Surgical Science, Department of Surgery, Columbia University Medical Center, 630 West 168th Street, P&S 17-501, New York, NY 10032, USA.
Curr Diab Rep. 2007 Apr;7(2):146-53. doi: 10.1007/s11892-007-0024-4.
The interaction of glucose-modified and inflammation-promoting ligands with the receptor for advanced glycation end products (RAGE) is emerging as a central mechanism contributing to the diverse complications of diabetes. These ligands, particularly in oligomeric form, bind to RAGE and transduce intracellular signals. The consequences of this interaction, as elucidated in cultured cells and animal models, include upregulation of inflammatory and tissue-degradative pathways. Pharmacologic antagonism of RAGE may hold promise for the treatment of diabetic complications.
葡萄糖修饰且促进炎症的配体与晚期糖基化终产物受体（RAGE）之间的相互作用正逐渐成为导致糖尿病多种并发症的核心机制。这些配体，尤其是寡聚形式，与RAGE结合并转导细胞内信号。在培养细胞和动物模型中所阐明的这种相互作用的后果包括炎症和组织降解途径的上调。RAGE的药理学拮抗作用可能为糖尿病并发症的治疗带来希望。
