Equipe d'Accueil (EA 7460): Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), Faculté des Sciences de Santé, Université de Bourgogne-Franche Comté, 7 Bd Jeanne d'Arc, 21000 Dijon, France.
Service de Cardiologie, CHU-Dijon, 21000 Dijon, France.
Cells. 2022 Apr 5;11(7):1226. doi: 10.3390/cells11071226.
Calprotectin (CLP) belonging to the S-100 protein family is a heterodimeric complex (S100A8/S100A9) formed by two binding proteins. Upon cell activation, CLP stored in neutrophils is released extracellularly in response to inflammatory stimuli and acts as damage-associated molecular patterns (DAMPs). S100A8 and S100A9 possess both anti-inflammatory and anti-bacterial properties. The complex is a ligand of the toll-like receptor 4 (TLR4) and receptor for advanced glycation end (RAGE). At sites of infection and inflammation, CLP is a target for oxidation due to its co-localization with neutrophil-derived oxidants. In the heart, oxidative stress (OS) responses and S100 proteins are closely related and intimately linked through pathophysiological processes. Our review summarizes the roles of S100A8, S100A9 and CLP in the inflammation in relationship with vascular OS, and we examine the importance of CLP for the mechanisms driving in the protection of myocardium. Recent evidence interpreting CLP as a critical modulator during the inflammatory response has identified this alarmin as an interesting drug target.
钙卫蛋白（CLP）属于 S-100 蛋白家族，是由两个结合蛋白组成的异二聚体复合物（S100A8/S100A9）。在细胞激活时，CLP 作为损伤相关分子模式（DAMPs），在炎症刺激下从嗜中性粒细胞中外泄到细胞外。S100A8 和 S100A9 具有抗炎和抗细菌特性。该复合物是 toll 样受体 4（TLR4）和晚期糖基化终产物受体（RAGE）的配体。在感染和炎症部位，CLP 是氧化的靶标，因为它与嗜中性粒细胞衍生的氧化剂共定位。在心脏中，氧化应激（OS）反应和 S100 蛋白密切相关，并通过病理生理过程紧密联系。我们的综述总结了 S100A8、S100A9 和 CLP 在与血管 OS 相关的炎症中的作用，并研究了 CLP 在驱动心肌保护机制中的重要性。最近的证据将 CLP 解释为炎症反应中的关键调节剂，将这种警报素鉴定为一个有趣的药物靶点。
