Longo F W, Tomashefsky P, Rivin B D, Longo W E, Lattimer J K, Willhite M, Tannenbaum M
Urology. 1976 Jan;7(1):80-4. doi: 10.1016/0090-4295(76)90570-7.
Local sonic irradiation was applied to subcutaneously implanted Furth-Columbia rat Wilms' tumor. The weight and the rate of tritiated thymidine uptake were measured in host organs distal to the application field. Kidney and spleen weights were inhibited by the Wilms' tumor, and sonication of the tumor removed all or part of this inhibition. Liver weight was increased after sonication of tumor-bearing rats but not in nontumor-bearing rats. This may have been a response to tumor-specific substances released into the circulation by sonic destruction of tumor tissue. The adrenals enlarged as a response to the stresses of both tumor-bearing and of sonication. Animals were implanted on both sides with the Wilms' tumor and on without any break in the growth curve while the sonicated right tumor was inhibited. These data suggest that the therapeutic effect of ultrasound is due solely to local factors and that systemic sequelae of some irradiation are unrelated to tumor inhibition.
对皮下植入Furth - 哥伦比亚大鼠肾母细胞瘤进行局部超声照射。测量照射区域远端宿主器官的重量以及氚标记胸腺嘧啶核苷摄取率。肾母细胞瘤会抑制肾脏和脾脏重量，而肿瘤的超声处理消除了全部或部分这种抑制作用。对荷瘤大鼠进行超声处理后肝脏重量增加，但对未荷瘤大鼠则无此现象。这可能是对肿瘤组织超声破坏后释放到循环系统中的肿瘤特异性物质的一种反应。肾上腺因荷瘤和超声处理的应激而增大。动物双侧植入肾母细胞瘤，在超声处理的右侧肿瘤受到抑制时，生长曲线无中断。这些数据表明，超声的治疗效果仅归因于局部因素，且某些照射的全身后遗症与肿瘤抑制无关。
