Longo F W, Tomashefsky P, Rivin B D, Longo W E, Lattimer J K, Tannenbaum M
Invest Urol. 1977 Jul;15(1):87-9.
The possible activation of immunologic defenses against tumor by local ultrasonic irradiation was investigated. Sonication of one tumor of a dual implant destroyed that tumor only with no contralateral effect. Injection of tumor cells previously sonicated in vivo did not induced immunity to subsequent challenge with live cells. Immunofluorescent staining of host kidneys for antibody complexes was negative. It was concluded that sonication was only effective when directly applied to the tumor.
研究了局部超声照射激活针对肿瘤的免疫防御的可能性。对双植入物中的一个肿瘤进行超声处理，仅破坏了该肿瘤，对侧没有影响。注射先前在体内进行过超声处理的肿瘤细胞，并未诱导对随后活细胞攻击的免疫反应。宿主肾脏抗体复合物的免疫荧光染色为阴性。得出的结论是，超声处理仅在直接应用于肿瘤时才有效。
