Gautam Amitabh, Fischer S A, Yango A F, Gohh R Y, Morrissey P E, Monaco A P
Division of Organ Transplantation, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA.
Transpl Infect Dis. 2007 Dec;9(4):339-42. doi: 10.1111/j.1399-3062.2007.00232.x. Epub 2007 Apr 11.
Infection with lymphocytic choriomeningitis virus (LCMV) in rodents, the primary host, is known to cause suppression of cell-mediated immunity. Serial determinations using a functional cell-mediated immune assay in a kidney transplant recipient with donor-transmitted LCMV also suggested profound suppression of cellular immunity. This suppression persisted in spite of reduction of immunosuppression. With the clearance of the virus there was reconstitution of the cellular immune response.
在主要宿主啮齿动物中，感染淋巴细胞性脉络丛脑膜炎病毒（LCMV）会导致细胞介导免疫的抑制。在一名因供体传播LCMV而感染的肾移植受者中，使用功能性细胞介导免疫测定法进行的系列测定也表明细胞免疫受到严重抑制。尽管免疫抑制有所减轻，但这种抑制仍然存在。随着病毒的清除，细胞免疫反应得以重建。
