Bános Z, Szeri I, Anderlik P
Institute of Microbiology, Semmelweis Medical University, Budapest, Hungary.
Acta Microbiol Immunol Hung. 1998;45(3-4):329-33.
Certain viruses do not kill the cells they infect. The immunological response of the host in such situations may be involved in the development of pathologic changes and clinical illness. Pioneering work by Rowe has shown that death associated with acute LCMV infection in the mouse is resulted from the immune response. Many investigators using a variety of techniques including neonatal thymectomy, irradiation, or treatment of adult mice with antilymphoid drugs or antithymocyte sera have confirmed and extended Rowe's observations. The study of LCMV and the disease it causes in its natural murine host has provided the initial findings that open new fields in viral immunobiology, viral immunopathology, and cell-cell recognition.
某些病毒不会杀死它们所感染的细胞。在这种情况下，宿主的免疫反应可能参与病理变化和临床疾病的发展。罗伊的开创性工作表明，小鼠急性淋巴细胞脉络丛脑膜炎病毒（LCMV）感染相关的死亡是由免疫反应导致的。许多研究人员使用了多种技术，包括新生小鼠胸腺切除、辐射，或用抗淋巴细胞药物或抗胸腺细胞血清治疗成年小鼠，证实并扩展了罗伊的观察结果。对LCMV及其在天然鼠宿主中引起的疾病的研究提供了初步发现，这些发现为病毒免疫生物学、病毒免疫病理学和细胞间识别开辟了新领域。
