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病理学在系统性血管炎诊断中的作用。

The role of pathology in the diagnosis of systemic vasculitis.

作者信息

Jennette J C, Falk R J

机构信息

Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill 27599-7525, USA.

出版信息

Clin Exp Rheumatol. 2007 Jan-Feb;25(1 Suppl 44):S52-6.

PMID:17428368
Abstract

Pathologic processes are underlying defining features of systemic vasculitis. When these pathologic processes can not be observed directly, surrogate signs and symptoms of disease must be used to conclude that vasculitis is present in a patient and, if so, to determine what specific type of vasculitis is present. This review briefly describes the most defining pathologic features of giant cell arteritis, Takayasu arteritis, polyarteritis nodosa, Henoch-Schönlein purpura, cryoglobulinemic vasculitis, Kawasaki disease, microscopic polyangiitis, Wegener's granulomatosis and Churg-Strauss syndrome; and discusses how these pathologic features can be integrated with clinical and laboratory data to reach an actionable diagnosis.

摘要

病理过程是系统性血管炎的根本特征。当这些病理过程无法直接观察到时,必须使用疾病的替代体征和症状来判断患者是否存在血管炎,如果存在,则确定是何种特定类型的血管炎。本综述简要描述了巨细胞动脉炎、大动脉炎、结节性多动脉炎、过敏性紫癜、冷球蛋白血症性血管炎、川崎病、显微镜下多血管炎、韦格纳肉芽肿和变应性肉芽肿性血管炎最具特征性的病理表现;并讨论了如何将这些病理特征与临床和实验室数据相结合以得出可行的诊断。

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