Plummer Chris, Kleinitz Anne, Vroomen Patrick, Watts Roger
Department of Neurology, Austin Hospital, Melbourne, Victoria.
J Clin Neurosci. 2007 Aug;14(8):709-14. doi: 10.1016/j.jocn.2006.08.006. Epub 2007 Apr 10.
Charles Bonnet syndrome (CBS) is a widely under-recognised disorder typically characterised by complex visual hallucinations in the visually impaired. The lack of consensus over a uniform definition for CBS has much to do with the unresolved pathophysiology of the disorder. A leading hypothesis proposes that complex hallucinations arise from visual association cortical areas following their de-afferentation from the central visual pathway. While treatment aimed at improving the visual deficit can limit the symptoms of CBS, at present there is no reliably effective pharmacotherapy for the disorder. Once correctly recognised, a key management principle is to reassure the patient that CBS is a well-documented clinical entity that is not a harbinger of psychiatric illness.
查尔斯·邦尼特综合征（CBS）是一种普遍未被充分认识的疾病，其典型特征是视力受损者出现复杂的视幻觉。对CBS缺乏统一的定义共识，这与该疾病尚未解决的病理生理学有很大关系。一个主要的假说是，复杂的幻觉源于视觉联合皮质区域，这些区域从中枢视觉通路去传入后产生。虽然旨在改善视力缺陷的治疗可以限制CBS的症状，但目前对于该疾病尚无可靠有效的药物疗法。一旦正确识别，一个关键的管理原则是让患者放心，CBS是一个有充分文献记载的临床实体，并非精神疾病的先兆。
