Karagezyan K G, Amirkhanyan L T, Amirkhanyan O M, Alexandryan D V
Vopr Med Khim. 1975 May-Jun;21(3):269-71.
In brain and liver tissue of rats, treated repeatedly with alcohol, alterations in content of total phospholipids and polyphosphoinositols were reproducibly different. In the tissues studied content of polyphosphoinositols were distinctly decreased. Independent function of phosphoinositols in tissue metabolism as an auxiliary energy system in addition to the universal adenylate system is considered. These concepts are in agreement with observations on development of rough morphological alterations (fatty degeneration) in liver tissue. The fatty degeneration developed in the liver tissue in response to deficiency of oxidative potential in the organ.
在反复用酒精处理的大鼠脑和肝组织中，总磷脂和多磷酸肌醇含量的变化呈现出可重复性差异。在所研究的组织中，多磷酸肌醇的含量明显降低。除了普遍的腺苷酸系统外，磷酸肌醇在组织代谢中作为辅助能量系统的独立功能也被考虑在内。这些概念与在肝组织中出现的粗糙形态学改变（脂肪变性）的观察结果一致。肝组织中的脂肪变性是由于器官氧化潜能不足而产生的。
