Miller Michelle A, Cappuccio Francesco P
Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, CV2 2DX, UK.
Curr Vasc Pharmacol. 2007 Apr;5(2):93-102. doi: 10.2174/157016107780368280.
Evidence is emerging that disturbances in sleep and sleep disorders play a role in the morbidity of chronic conditions. However, the relationship between sleep processes, disease development, disease progression and disease management is often unclear or understudied. Numerous common medical conditions can have an affect on sleep. For example, diabetes or inflammatory conditions such as arthritis can lead to poor sleep quality and induce symptoms of excessive daytime sleepiness and fatigue. It has also been suggested that poor sleep may lead to the development of cardiovascular disease for which an underlying inflammatory component has been proposed. It is therefore important that the development and progression of such disease states are studied to determine whether the sleep effect merely reflects disease progression or whether it may be in some way causally related. Sleep loss can also have consequences on safety related behaviours both for the individuals and for the society, for example the increased risk of accidents when driving while drowsy. Sleep is a complex phenotype and as such it is possible that there are numerous genes which may each have a number of effects that control an individual's sleep pattern. This review examines the interaction between sleep (both quantity and quality) and parameters of cardiovascular risk. We also explore the hypothesis that inflammation plays an essential role in cardiovascular disease and that a lack of sleep may play a key role in this inflammatory process.
To review current evidence regarding the endocrine, metabolic, cardiovascular and immune functions and their interactions with regard to sleep, given the current evidence that sleep disturbances may affect each of these areas.
越来越多的证据表明，睡眠障碍和睡眠失调在慢性病的发病过程中起作用。然而，睡眠过程、疾病发展、疾病进展和疾病管理之间的关系往往不明确或研究不足。许多常见的医疗状况会影响睡眠。例如，糖尿病或关节炎等炎症性疾病会导致睡眠质量差，并引发白天过度嗜睡和疲劳的症状。也有人提出，睡眠不足可能会导致心血管疾病的发生，而心血管疾病存在潜在的炎症成分。因此，研究这些疾病状态的发展和进展很重要，以确定睡眠影响仅仅反映疾病进展，还是在某种程度上可能存在因果关系。睡眠不足也会对个人和社会的安全相关行为产生影响，例如，困倦驾驶时事故风险增加。睡眠是一种复杂的表型，因此可能有许多基因，每个基因可能有多种影响，控制个体的睡眠模式。本综述探讨睡眠（数量和质量）与心血管风险参数之间的相互作用。我们还探讨了炎症在心血管疾病中起关键作用，而睡眠不足可能在这一炎症过程中起关键作用的假说。
鉴于目前有证据表明睡眠障碍可能影响这些领域中的每一个领域，综述有关睡眠的内分泌、代谢、心血管和免疫功能及其相互作用的现有证据。
