Ahuja S, Schiller S, Ernst H
Abteilung Strahlentherapie, Universitätsklinikum Steglitz, Freie Universität Berlin, Federal Republic of Germany.
Eur J Nucl Med. 1991;18(10):791-5. doi: 10.1007/BF00175056.
Samples of fresh thyroid tissue obtained from 15 patients undergoing thyroid surgery were incubated with iodine 125 in culture solution to which thyroid-stimulating hormone (TSH) had been added and then examined by autoradiography. The radioactivity registered actively during the 90-min incubation period was primarily found in the lumina of follicles. Even morphologically similar follicles showed very heterogeneous uptake of radioiodine; small follicles often contained the highest concentrations of activity. The method applied appears to be particularly useful for answering the question as to whether and to what extent individual papillary or follicular thyroid carcinomas are able to store radioiodine. This information obtained immediately after surgery may contribute towards establishing the patient's prognosis and help in deciding on postoperative therapy and follow-up. Because of the heterogeneity of radioiodine uptake, it is mandatory to examine a representative sample of carcinoma tissue in order to obtain well-established results.
从15例接受甲状腺手术的患者身上获取新鲜甲状腺组织样本，将其置于添加了促甲状腺激素（TSH）的培养液中与碘125一起孵育，然后通过放射自显影进行检查。在90分钟的孵育期内活跃记录到的放射性主要存在于滤泡腔内。即使形态相似的滤泡也显示出放射性碘摄取非常不均匀；小滤泡通常含有最高浓度的活性。所应用的方法似乎对于回答个别甲状腺乳头状癌或滤泡状癌是否能够以及在何种程度上储存放射性碘这一问题特别有用。术后立即获得的这些信息可能有助于确定患者的预后，并有助于决定术后治疗和随访。由于放射性碘摄取的不均匀性，为了获得确切的结果，必须检查癌组织的代表性样本。
