Goss-Sampson M A, Muller D P, Kriss A
Department of Child Health, Institute of Child Health, London, U.K.
Exp Eye Res. 1991 Nov;53(5):623-7. doi: 10.1016/0014-4835(91)90222-z.
Flash electroretinograms, retinal oscillatory and cortical visual-evoked potentials were recorded in 10-month vitamin E deficient rats and in age-matched controls. A significant increase in the latency (P less than 0.0001) and decrease in amplitude (P less than 0.0001) of the electroretinogram a- and b-waves were observed in the vitamin E deficient rats compared with controls. The vitamin E deficient rats also showed a significant delay (P less than 0.002) in early oscillatory potentials. No significant group differences were obtained in the P1 latency or P1-N1 amplitude of the visual-evoked potential; however, the N1 peak was significantly delayed (P = 0.01) in the vitamin E deficient rats. This study shows, for the first time, that the electroretinogram and visual-evoked potential to flash stimulation provide a sensitive index for monitoring the visual effects of vitamin E deficiency in the rat.
对10月龄维生素E缺乏大鼠和年龄匹配的对照大鼠记录了闪光视网膜电图、视网膜振荡电位和皮质视觉诱发电位。与对照组相比，维生素E缺乏大鼠的视网膜电图a波和b波潜伏期显著延长（P<0.0001），波幅降低（P<0.0001）。维生素E缺乏大鼠的早期振荡电位也显著延迟（P<0.002）。视觉诱发电位的P1潜伏期或P1-N1波幅在两组间无显著差异；然而，维生素E缺乏大鼠的N1峰显著延迟（P = 0.01）。本研究首次表明，闪光刺激的视网膜电图和视觉诱发电位为监测大鼠维生素E缺乏的视觉效应提供了一个敏感指标。
